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Interactions between Membrane Resistance, GABA-A Receptor Properties, Bicarbonate Dynamics and Cl(−)-Transport Shape Activity-Dependent Changes of Intracellular Cl(−) Concentration

The effects of ionotropic γ-aminobutyric acid receptor (GABA-A, GABA(A)) activation depends critically on the Cl(−)-gradient across neuronal membranes. Previous studies demonstrated that the intracellular Cl(−)-concentration ([Cl(−)](i)) is not stable but shows a considerable amount of activity-depe...

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Detalles Bibliográficos
Autores principales: Lombardi, Aniello, Jedlicka, Peter, Luhmann, Heiko J., Kilb, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471822/
https://www.ncbi.nlm.nih.gov/pubmed/30897846
http://dx.doi.org/10.3390/ijms20061416