OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor

BACKGROUND: Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent state. Howe...

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Detalles Bibliográficos
Autores principales: Zhang, Shuchen, Bell, Emma, Zhi, Huihan, Brown, Sarah, Imran, Siti A. M., Azuara, Véronique, Cui, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471829/
https://www.ncbi.nlm.nih.gov/pubmed/30999923
http://dx.doi.org/10.1186/s13287-019-1228-7

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