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Pharmacological inhibition of EZH2 combined with DNA-damaging agents interferes with the DNA damage response in MM cells

Enhancer of zeste homolog 2 (EZH2) serves a pivotal role in epigenetic silencing by acting as a histone methyltransferase. It has been confirmed that EZH2 overexpression occurs in different types of cancer and is involved in drug resistance, while it remains unclear how a DNA-damaging event may prom...

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Detalles Bibliográficos
Autores principales:	Xu, Li, Tang, Hailong, Wang, Kai, Zheng, Yanhua, Feng, Juan, Dong, Hongjuan, Jin, Yulong, Cao, Chun, Chen, Xiequn, Gao, Guangxun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471932/ https://www.ncbi.nlm.nih.gov/pubmed/30942459 http://dx.doi.org/10.3892/mmr.2019.10075

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