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The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence
Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption is coupled with bone formation to maintain the bone volume and microarchitecture. This process is a result of communication...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471965/ https://www.ncbi.nlm.nih.gov/pubmed/30909398 http://dx.doi.org/10.3390/ijms20061453 |
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author | Wong, Sok Kuan Mohamad, Nur-Vaizura Ibrahim, Nurul ‘Izzah Chin, Kok-Yong Shuid, Ahmad Nazrun Ima-Nirwana, Soelaiman |
author_facet | Wong, Sok Kuan Mohamad, Nur-Vaizura Ibrahim, Nurul ‘Izzah Chin, Kok-Yong Shuid, Ahmad Nazrun Ima-Nirwana, Soelaiman |
author_sort | Wong, Sok Kuan |
collection | PubMed |
description | Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption is coupled with bone formation to maintain the bone volume and microarchitecture. This process is a result of communication between bone cells (osteoclasts, osteoblasts, and osteocytes) with paracrine and endocrine regulators, such as cytokines, reactive oxygen species, growth factors, and hormones. The essential signalling pathways responsible for osteoclastic bone resorption and osteoblastic bone formation include the receptor activator of nuclear factor kappa-B (RANK)/receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG), Wnt/β-catenin, and oxidative stress signalling. The imbalance between bone formation and degradation, in favour of resorption, leads to the occurrence of osteoporosis. Intriguingly, vitamin E has been extensively reported for its anti-osteoporotic properties using various male and female animal models. Thus, understanding the underlying cellular and molecular mechanisms contributing to the skeletal action of vitamin E is vital to promote its use as a potential bone-protecting agent. This review aims to summarize the current evidence elucidating the molecular actions of vitamin E in regulating the bone remodelling cycle. |
format | Online Article Text |
id | pubmed-6471965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64719652019-04-26 The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence Wong, Sok Kuan Mohamad, Nur-Vaizura Ibrahim, Nurul ‘Izzah Chin, Kok-Yong Shuid, Ahmad Nazrun Ima-Nirwana, Soelaiman Int J Mol Sci Review Bone remodelling is a tightly-coordinated and lifelong process of replacing old damaged bone with newly-synthesized healthy bone. In the bone remodelling cycle, bone resorption is coupled with bone formation to maintain the bone volume and microarchitecture. This process is a result of communication between bone cells (osteoclasts, osteoblasts, and osteocytes) with paracrine and endocrine regulators, such as cytokines, reactive oxygen species, growth factors, and hormones. The essential signalling pathways responsible for osteoclastic bone resorption and osteoblastic bone formation include the receptor activator of nuclear factor kappa-B (RANK)/receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG), Wnt/β-catenin, and oxidative stress signalling. The imbalance between bone formation and degradation, in favour of resorption, leads to the occurrence of osteoporosis. Intriguingly, vitamin E has been extensively reported for its anti-osteoporotic properties using various male and female animal models. Thus, understanding the underlying cellular and molecular mechanisms contributing to the skeletal action of vitamin E is vital to promote its use as a potential bone-protecting agent. This review aims to summarize the current evidence elucidating the molecular actions of vitamin E in regulating the bone remodelling cycle. MDPI 2019-03-22 /pmc/articles/PMC6471965/ /pubmed/30909398 http://dx.doi.org/10.3390/ijms20061453 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wong, Sok Kuan Mohamad, Nur-Vaizura Ibrahim, Nurul ‘Izzah Chin, Kok-Yong Shuid, Ahmad Nazrun Ima-Nirwana, Soelaiman The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title | The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title_full | The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title_fullStr | The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title_full_unstemmed | The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title_short | The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence |
title_sort | molecular mechanism of vitamin e as a bone-protecting agent: a review on current evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471965/ https://www.ncbi.nlm.nih.gov/pubmed/30909398 http://dx.doi.org/10.3390/ijms20061453 |
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