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Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471987/ https://www.ncbi.nlm.nih.gov/pubmed/30866565 http://dx.doi.org/10.3390/nu11030576 |
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author | Muralidharan, Jananee Papandreou, Christopher Sala-Vila, Aleix Rosique-Esteban, Nuria Fitó, Montserrat Estruch, Ramon Angel Martínez-González, Miguel Corella, Dolores Ros, Emilio Razquín, Cristina Castañer, Olga Salas-Salvadó, Jordi Bulló, Monica |
author_facet | Muralidharan, Jananee Papandreou, Christopher Sala-Vila, Aleix Rosique-Esteban, Nuria Fitó, Montserrat Estruch, Ramon Angel Martínez-González, Miguel Corella, Dolores Ros, Emilio Razquín, Cristina Castañer, Olga Salas-Salvadó, Jordi Bulló, Monica |
author_sort | Muralidharan, Jananee |
collection | PubMed |
description | There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. |
format | Online Article Text |
id | pubmed-6471987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64719872019-04-25 Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis Muralidharan, Jananee Papandreou, Christopher Sala-Vila, Aleix Rosique-Esteban, Nuria Fitó, Montserrat Estruch, Ramon Angel Martínez-González, Miguel Corella, Dolores Ros, Emilio Razquín, Cristina Castañer, Olga Salas-Salvadó, Jordi Bulló, Monica Nutrients Article There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. MDPI 2019-03-07 /pmc/articles/PMC6471987/ /pubmed/30866565 http://dx.doi.org/10.3390/nu11030576 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Muralidharan, Jananee Papandreou, Christopher Sala-Vila, Aleix Rosique-Esteban, Nuria Fitó, Montserrat Estruch, Ramon Angel Martínez-González, Miguel Corella, Dolores Ros, Emilio Razquín, Cristina Castañer, Olga Salas-Salvadó, Jordi Bulló, Monica Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title_full | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title_fullStr | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title_full_unstemmed | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title_short | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
title_sort | fatty acids composition of blood cell membranes and peripheral inflammation in the predimed study: a cross-sectional analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471987/ https://www.ncbi.nlm.nih.gov/pubmed/30866565 http://dx.doi.org/10.3390/nu11030576 |
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