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Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis

There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes...

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Autores principales: Muralidharan, Jananee, Papandreou, Christopher, Sala-Vila, Aleix, Rosique-Esteban, Nuria, Fitó, Montserrat, Estruch, Ramon, Angel Martínez-González, Miguel, Corella, Dolores, Ros, Emilio, Razquín, Cristina, Castañer, Olga, Salas-Salvadó, Jordi, Bulló, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471987/
https://www.ncbi.nlm.nih.gov/pubmed/30866565
http://dx.doi.org/10.3390/nu11030576
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author Muralidharan, Jananee
Papandreou, Christopher
Sala-Vila, Aleix
Rosique-Esteban, Nuria
Fitó, Montserrat
Estruch, Ramon
Angel Martínez-González, Miguel
Corella, Dolores
Ros, Emilio
Razquín, Cristina
Castañer, Olga
Salas-Salvadó, Jordi
Bulló, Monica
author_facet Muralidharan, Jananee
Papandreou, Christopher
Sala-Vila, Aleix
Rosique-Esteban, Nuria
Fitó, Montserrat
Estruch, Ramon
Angel Martínez-González, Miguel
Corella, Dolores
Ros, Emilio
Razquín, Cristina
Castañer, Olga
Salas-Salvadó, Jordi
Bulló, Monica
author_sort Muralidharan, Jananee
collection PubMed
description There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes.
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spelling pubmed-64719872019-04-25 Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis Muralidharan, Jananee Papandreou, Christopher Sala-Vila, Aleix Rosique-Esteban, Nuria Fitó, Montserrat Estruch, Ramon Angel Martínez-González, Miguel Corella, Dolores Ros, Emilio Razquín, Cristina Castañer, Olga Salas-Salvadó, Jordi Bulló, Monica Nutrients Article There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. MDPI 2019-03-07 /pmc/articles/PMC6471987/ /pubmed/30866565 http://dx.doi.org/10.3390/nu11030576 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muralidharan, Jananee
Papandreou, Christopher
Sala-Vila, Aleix
Rosique-Esteban, Nuria
Fitó, Montserrat
Estruch, Ramon
Angel Martínez-González, Miguel
Corella, Dolores
Ros, Emilio
Razquín, Cristina
Castañer, Olga
Salas-Salvadó, Jordi
Bulló, Monica
Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title_full Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title_fullStr Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title_full_unstemmed Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title_short Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
title_sort fatty acids composition of blood cell membranes and peripheral inflammation in the predimed study: a cross-sectional analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471987/
https://www.ncbi.nlm.nih.gov/pubmed/30866565
http://dx.doi.org/10.3390/nu11030576
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