Cargando…

Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol

Objective: Tumor necrosis factor-beta (TNF-β), as an inflammatory mediator that has been shown to promote tumorigenesis, induces NF-κB. Natural multi-targeted agent resveratrol in turn shows anti-inflammatory and anti-cancer properties. Epithelial-to-mesenchymal transition (EMT) allows cancer cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buhrmann, Constanze, Yazdi, Mina, Popper, Bastian, Kunnumakkara, Ajaikumar B., Aggarwal, Bharat B., Shakibaei, Mehdi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471988/ https://www.ncbi.nlm.nih.gov/pubmed/30917533 http://dx.doi.org/10.3390/nu11030704

Ejemplares similares

Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-κB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin)
por: Buhrmann, Constanze, et al.
Publicado: (2019)

Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB †
por: Buhrmann, Constanze, et al.
Publicado: (2020)

Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α
por: Buhrmann, Constanze, et al.
Publicado: (2017)

Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes
por: Buhrmann, Constanze, et al.
Publicado: (2013)

Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells
por: Buhrmann, Constanze, et al.
Publicado: (2018)

Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment
por: Buhrmann, Constanze, et al.
Publicado: (2021)

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
por: Buhrmann, Constanze, et al.
Publicado: (2021)

Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells
por: Buhrmann, Constanze, et al.
Publicado: (2016)

Targeting NF-κB Signaling by Calebin A, a Compound of Turmeric, in Multicellular Tumor Microenvironment: Potential Role of Apoptosis Induction in CRC Cells
por: Buhrmann, Constanze, et al.
Publicado: (2020)

Resveratrol Modulates Chemosensitisation to 5-FU via β1-Integrin/HIF-1α Axis in CRC Tumor Microenvironment
por: Brockmueller, Aranka, et al.
Publicado: (2023)

Multifunctionality of Calebin A in inflammation, chronic diseases and cancer
por: Brockmueller, Aranka, et al.
Publicado: (2022)

Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules
por: Buhrmann, Constanze, et al.
Publicado: (2017)

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer
por: Shakibaei, Mehdi, et al.
Publicado: (2015)

Resveratrol induces apoptosis by modulating the reciprocal crosstalk between p53 and Sirt-1 in the CRC tumor microenvironment
por: Brockmueller, Aranka, et al.
Publicado: (2023)

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells
por: Shakibaei, Mehdi, et al.
Publicado: (2011)

Resveratrol Suppresses Cross-Talk between Colorectal Cancer Cells and Stromal Cells in Multicellular Tumor Microenvironment: A Bridge between In Vitro and In Vivo Tumor Microenvironment Study
por: Buhrmann, Constanze, et al.
Publicado: (2020)

Calebin A, a Compound of Turmeric, Down-Regulates Inflammation in Tenocytes by NF-κB/Scleraxis Signaling
por: Mueller, Anna-Lena, et al.
Publicado: (2022)

Modulation of Inflammation by Plant-Derived Nutraceuticals in Tendinitis
por: Mueller, Anna-Lena, et al.
Publicado: (2022)

Calebin A targets the HIF-1α/NF-κB pathway to suppress colorectal cancer cell migration
por: Brockmueller, Aranka, et al.
Publicado: (2023)

Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation
por: Shakibaei, Mehdi, et al.
Publicado: (2012)

Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases
por: Gupta, Subash Chandra, et al.
Publicado: (2018)

Curcumin, inflammation, and neurological disorders: How are they linked?
por: Garodia, Prachi, et al.
Publicado: (2023)

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
por: Csaki, Constanze, et al.
Publicado: (2009)

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures
por: Shakibaei, Mehdi, et al.
Publicado: (2014)

Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
por: Buhrmann, Constanze, et al.
Publicado: (2010)

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytes in Vitro: ROLE OF THE PHOSPHATIDYLINOSITOL 3-KINASE/Akt PATHWAY
por: Buhrmann, Constanze, et al.
Publicado: (2011)

Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes
por: O'Connor, Tracy, et al.
Publicado: (2012)

Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis
por: Lorenz, Wolfgang, et al.
Publicado: (2013)

Curcumin Attenuates Environment-Derived Osteoarthritis by Sox9/NF-kB Signaling Axis
por: Buhrmann, Constanze, et al.
Publicado: (2021)

Differential Expression of Genes Regulating Store-operated Calcium Entry in Conjunction With Mitochondrial Dynamics as Potential Biomarkers for Cancer: A Single-Cell RNA Analysis
por: Hegde, Mangala, et al.
Publicado: (2022)

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT
por: Buhrmann, Constanze, et al.
Publicado: (2014)

Herbal Remedies as Potential in Cartilage Tissue Engineering: An Overview of New Therapeutic Approaches and Strategies
por: Buhrmann, Constanze, et al.
Publicado: (2020)

Bacteria-Mediated Modulatory Strategies for Colorectal Cancer Treatment
por: Mueller, Anna-Lena, et al.
Publicado: (2022)

Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration
por: Guo, Zhu, et al.
Publicado: (2021)

Lymphotoxin expression in human and murine renal allografts
por: Seeger, Harald, et al.
Publicado: (2018)

Organophosphorus Compounds and MAPK Signaling Pathways
por: Farkhondeh, Tahereh, et al.
Publicado: (2020)

Cancer is a Preventable Disease that Requires Major Lifestyle Changes
por: Anand, Preetha, et al.
Publicado: (2008)

Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin
Publicado: (1984)

IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway
por: Montaseri, Azadeh, et al.
Publicado: (2011)

Chronic diseases, inflammation, and spices: how are they linked?
por: Kunnumakkara, Ajaikumar B., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vmgi0b81vtamhch097p22dqcbp