Loss of sphingosine 1-phosphate (S1P) in septic shock is predominantly caused by decreased levels of high-density lipoproteins (HDL)

BACKGROUND: Sphingosine 1-phosphate (S1P) is a signaling lipid essential in regulating processes involved in sepsis pathophysiology, including endothelial permeability and vascular tone. Serum S1P is progressively reduced in sepsis patients with increasing severity. S1P function depends on binding t...

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Detalles Bibliográficos
Autores principales: Winkler, Martin Sebastian, Märtz, Konstantin B., Nierhaus, Axel, Daum, Günter, Schwedhelm, Edzard, Kluge, Stefan, Gräler, Markus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472014/
https://www.ncbi.nlm.nih.gov/pubmed/31019718
http://dx.doi.org/10.1186/s40560-019-0376-2

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