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Removal of alleles by genome editing (RAGE) against deleterious load

BACKGROUND: In this paper, we simulate deleterious load in an animal breeding program, and compare the efficiency of genome editing and selection for decreasing it. Deleterious variants can be identified by bioinformatics screening methods that use sequence conservation and biological prior informat...

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Detalles Bibliográficos
Autores principales:	Johnsson, Martin, Gaynor, R. Chris, Jenko, Janez, Gorjanc, Gregor, de Koning, Dirk-Jan, Hickey, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472060/ https://www.ncbi.nlm.nih.gov/pubmed/30995904 http://dx.doi.org/10.1186/s12711-019-0456-8

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