Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers

Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differe...

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Autores principales: Song, Yizuo, Lin, Min, Liu, Yi, Wang, Zhi-Wei, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472071/
https://www.ncbi.nlm.nih.gov/pubmed/30999935
http://dx.doi.org/10.1186/s13287-019-1222-0
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author Song, Yizuo
Lin, Min
Liu, Yi
Wang, Zhi-Wei
Zhu, Xueqiong
author_facet Song, Yizuo
Lin, Min
Liu, Yi
Wang, Zhi-Wei
Zhu, Xueqiong
author_sort Song, Yizuo
collection PubMed
description Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differentiation in human cancers. In this review, we will briefly describe the role of EMT and stem cells in cell metastasis and drug resistance. We will also highlight how numerous F-box proteins govern the EMT process and stem cell survival by controlling their downstream targets. Additionally, we will discuss whether F-box proteins involved in drug resistance are associated with EMT and cancer stem cells. Targeting these F-box proteins might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers.
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spelling pubmed-64720712019-04-24 Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers Song, Yizuo Lin, Min Liu, Yi Wang, Zhi-Wei Zhu, Xueqiong Stem Cell Res Ther Review Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differentiation in human cancers. In this review, we will briefly describe the role of EMT and stem cells in cell metastasis and drug resistance. We will also highlight how numerous F-box proteins govern the EMT process and stem cell survival by controlling their downstream targets. Additionally, we will discuss whether F-box proteins involved in drug resistance are associated with EMT and cancer stem cells. Targeting these F-box proteins might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers. BioMed Central 2019-04-18 /pmc/articles/PMC6472071/ /pubmed/30999935 http://dx.doi.org/10.1186/s13287-019-1222-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Song, Yizuo
Lin, Min
Liu, Yi
Wang, Zhi-Wei
Zhu, Xueqiong
Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title_full Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title_fullStr Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title_full_unstemmed Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title_short Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
title_sort emerging role of f-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472071/
https://www.ncbi.nlm.nih.gov/pubmed/30999935
http://dx.doi.org/10.1186/s13287-019-1222-0
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