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Influence of the Elastic Modulus on the Osseointegration of Dental Implants

The load transfer from metallic prosthesis to tissue plays an important role in the success of a designed device. From a mechanical behavior point of view, the load transfer will be favored when the elastic modulus between the metallic implant and the bone tissue are similar. Titanium and Ti-6Al-4V...

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Autores principales: Brizuela, Aritza, Herrero-Climent, Mariano, Rios-Carrasco, Elisa, Rios-Santos, Jose Vicente, Pérez, Roman A., Manero, Jose Maria, Gil Mur, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472162/
https://www.ncbi.nlm.nih.gov/pubmed/30934553
http://dx.doi.org/10.3390/ma12060980
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author Brizuela, Aritza
Herrero-Climent, Mariano
Rios-Carrasco, Elisa
Rios-Santos, Jose Vicente
Pérez, Roman A.
Manero, Jose Maria
Gil Mur, Javier
author_facet Brizuela, Aritza
Herrero-Climent, Mariano
Rios-Carrasco, Elisa
Rios-Santos, Jose Vicente
Pérez, Roman A.
Manero, Jose Maria
Gil Mur, Javier
author_sort Brizuela, Aritza
collection PubMed
description The load transfer from metallic prosthesis to tissue plays an important role in the success of a designed device. From a mechanical behavior point of view, the load transfer will be favored when the elastic modulus between the metallic implant and the bone tissue are similar. Titanium and Ti-6Al-4V are the most commonly used metals and alloys in the field of dental implants, although they present high elastic moduli and hence trigger bone resorption. We propose the use of low-modulus β-type titanium alloys that can improve the growth of new bone surrounding the implant. We designed dental implants with identical morphology and micro-roughness composed of: Ti-15Zr, Ti-19.1Nb-8.8Zr, Ti-41.2Nb-6.1Zr, and Ti-25Hf-25Ta. The commercially pure Ti cp and Ti-6Al-4V were used as control samples. The alloys were initially mechanically characterized with a tensile test using a universal testing machine. The results showed the lowest elastic modulus for the Ti-25Hf-25Ta alloy. We implanted a total of six implants in the mandible (3) and maxilla (3) for each titanium alloy in six minipigs and evaluated their bone index contact (i.e., the percentage of new bone in contact with the metal—BIC%) after 3 and 6 weeks of implantation. The results showed higher BIC% for the dental implants with lowest elastic modulus, showing the importance of decreasing the elastic modulus of alloys for the successful osseointegration of dental implants.
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spelling pubmed-64721622019-04-27 Influence of the Elastic Modulus on the Osseointegration of Dental Implants Brizuela, Aritza Herrero-Climent, Mariano Rios-Carrasco, Elisa Rios-Santos, Jose Vicente Pérez, Roman A. Manero, Jose Maria Gil Mur, Javier Materials (Basel) Article The load transfer from metallic prosthesis to tissue plays an important role in the success of a designed device. From a mechanical behavior point of view, the load transfer will be favored when the elastic modulus between the metallic implant and the bone tissue are similar. Titanium and Ti-6Al-4V are the most commonly used metals and alloys in the field of dental implants, although they present high elastic moduli and hence trigger bone resorption. We propose the use of low-modulus β-type titanium alloys that can improve the growth of new bone surrounding the implant. We designed dental implants with identical morphology and micro-roughness composed of: Ti-15Zr, Ti-19.1Nb-8.8Zr, Ti-41.2Nb-6.1Zr, and Ti-25Hf-25Ta. The commercially pure Ti cp and Ti-6Al-4V were used as control samples. The alloys were initially mechanically characterized with a tensile test using a universal testing machine. The results showed the lowest elastic modulus for the Ti-25Hf-25Ta alloy. We implanted a total of six implants in the mandible (3) and maxilla (3) for each titanium alloy in six minipigs and evaluated their bone index contact (i.e., the percentage of new bone in contact with the metal—BIC%) after 3 and 6 weeks of implantation. The results showed higher BIC% for the dental implants with lowest elastic modulus, showing the importance of decreasing the elastic modulus of alloys for the successful osseointegration of dental implants. MDPI 2019-03-25 /pmc/articles/PMC6472162/ /pubmed/30934553 http://dx.doi.org/10.3390/ma12060980 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brizuela, Aritza
Herrero-Climent, Mariano
Rios-Carrasco, Elisa
Rios-Santos, Jose Vicente
Pérez, Roman A.
Manero, Jose Maria
Gil Mur, Javier
Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title_full Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title_fullStr Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title_full_unstemmed Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title_short Influence of the Elastic Modulus on the Osseointegration of Dental Implants
title_sort influence of the elastic modulus on the osseointegration of dental implants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472162/
https://www.ncbi.nlm.nih.gov/pubmed/30934553
http://dx.doi.org/10.3390/ma12060980
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