Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease and Huntington’s disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have soug...

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Detalles Bibliográficos
Autores principales: Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472390/
https://www.ncbi.nlm.nih.gov/pubmed/31000720
http://dx.doi.org/10.1038/s41467-019-09494-2

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