Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living c...

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Detalles Bibliográficos
Autores principales: Harnoš, Jakub, Cañizal, Maria Consuelo Alonso, Jurásek, Miroslav, Kumar, Jitender, Holler, Cornelia, Schambony, Alexandra, Hanáková, Kateřina, Bernatík, Ondřej, Zdráhal, Zbyněk, Gömöryová, Kristína, Gybeľ, Tomáš, Radaszkiewicz, Tomasz Witold, Kravec, Marek, Trantírek, Lukáš, Ryneš, Jan, Dave, Zankruti, Fernández-Llamazares, Ana Iris, Vácha, Robert, Tripsianes, Konstantinos, Hoffmann, Carsten, Bryja, Vítězslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472409/
https://www.ncbi.nlm.nih.gov/pubmed/31000703
http://dx.doi.org/10.1038/s41467-019-09651-7

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