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Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke
The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute commo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472418/ https://www.ncbi.nlm.nih.gov/pubmed/31000730 http://dx.doi.org/10.1038/s41598-019-42594-z |
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author | Enevold, C. Nielsen, C. H. Molbo, D. Lund, R. Bendtzen, K. Fiehn, N. -E. Holmstrup, P. |
author_facet | Enevold, C. Nielsen, C. H. Molbo, D. Lund, R. Bendtzen, K. Fiehn, N. -E. Holmstrup, P. |
author_sort | Enevold, C. |
collection | PubMed |
description | The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a−b−) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72–131.63). |
format | Online Article Text |
id | pubmed-6472418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64724182019-04-25 Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke Enevold, C. Nielsen, C. H. Molbo, D. Lund, R. Bendtzen, K. Fiehn, N. -E. Holmstrup, P. Sci Rep Article The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a−b−) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72–131.63). Nature Publishing Group UK 2019-04-18 /pmc/articles/PMC6472418/ /pubmed/31000730 http://dx.doi.org/10.1038/s41598-019-42594-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Enevold, C. Nielsen, C. H. Molbo, D. Lund, R. Bendtzen, K. Fiehn, N. -E. Holmstrup, P. Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title | Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title_full | Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title_fullStr | Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title_full_unstemmed | Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title_short | Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
title_sort | lewis and ab0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472418/ https://www.ncbi.nlm.nih.gov/pubmed/31000730 http://dx.doi.org/10.1038/s41598-019-42594-z |
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