Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration

Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an...

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Autores principales: Kochendoerfer, Kiara, Sa Gomes, Pedro, Rütze, Dennis N., Pathapati, Trinath, de Wit, Pieter, Zaalberg, Menne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472593/
https://www.ncbi.nlm.nih.gov/pubmed/31007409
http://dx.doi.org/10.1002/ceat.201800298
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author Kochendoerfer, Kiara
Sa Gomes, Pedro
Rütze, Dennis N.
Pathapati, Trinath
de Wit, Pieter
Zaalberg, Menne
author_facet Kochendoerfer, Kiara
Sa Gomes, Pedro
Rütze, Dennis N.
Pathapati, Trinath
de Wit, Pieter
Zaalberg, Menne
author_sort Kochendoerfer, Kiara
collection PubMed
description Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ‐aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product‐containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation.
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spelling pubmed-64725932019-04-19 Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration Kochendoerfer, Kiara Sa Gomes, Pedro Rütze, Dennis N. Pathapati, Trinath de Wit, Pieter Zaalberg, Menne Chem Eng Technol Research Articles Complex streams in bio‐based industries require efficient downstream processing units. Simulated moving‐bed (SMB) chromatography is known to improve process efficiency by reducing resin and buffer requirement, but it can be further enhanced by technology hybridization. In the current experiments, an SMB system has been integrated with a bipolar electrodialysis (BPED) system. SMB purified γ‐aminobutyric acid (GABA) from a clarified fermentation broth while BPED processed the product‐containing eluent stream into recyclable eluent and purified product streams. The continuous operation did not result in any impurity accumulation. John Wiley and Sons Inc. 2018-10-30 2018-12 /pmc/articles/PMC6472593/ /pubmed/31007409 http://dx.doi.org/10.1002/ceat.201800298 Text en © 2018 The Authors. Chemical Engineering & Technology is published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Kochendoerfer, Kiara
Sa Gomes, Pedro
Rütze, Dennis N.
Pathapati, Trinath
de Wit, Pieter
Zaalberg, Menne
Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title_full Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title_fullStr Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title_full_unstemmed Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title_short Hybridizing Simulated Moving Bed and Electrodialysis: Product Purification and Eluent Regeneration
title_sort hybridizing simulated moving bed and electrodialysis: product purification and eluent regeneration
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472593/
https://www.ncbi.nlm.nih.gov/pubmed/31007409
http://dx.doi.org/10.1002/ceat.201800298
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