Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors

Angiotensin-I converting enzyme (ACE) is a two-domain dipeptidylcarboxypeptidase involved in regulating blood pressure via the kallikrein-kininand renin-angiotensin-aldosterone complex. Therefore, ACE is a key drug target for the treatment of cardiovascular system diseases. At present many works are...

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Detalles Bibliográficos
Autores principales: Fang, Li, Geng, Mingxian, Liu, Chunlei, Wang, Ji, Min, Weihong, Liu, Jingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472769/
https://www.ncbi.nlm.nih.gov/pubmed/30998765
http://dx.doi.org/10.1371/journal.pone.0215609

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