MAW point mutation impairs H. Seropedicae RecA ATP hydrolysis and DNA repair without inducing large conformational changes in its structure

RecA is a multifunctional protein that plays a central role in DNA repair in bacteria. The structural Make ATP Work motif (MAW) is proposed to control the ATPase activity of RecA. In the present work, we report the biochemical activity and structural effects of the L53Q mutation at the MAW motif of...

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Detalles Bibliográficos
Autores principales: Leite, Wellington C., Penteado, Renato F., Gomes, Fernando, Iulek, Jorge, Etto, Rafael M., Saab, Sérgio C., Steffens, Maria B. R., Galvão, Carolina W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472873/
https://www.ncbi.nlm.nih.gov/pubmed/30998678
http://dx.doi.org/10.1371/journal.pone.0214601

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