Cargando…

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts or exposure to blast waves. First described as punch-drunk syndrome and dementia pugilistica in retired boxers(1-3), CTE has since been identified in former participants of other contact s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Falcon, Benjamin, Zivanov, Jasenko, Zhang, Wenjuan, Murzin, Alexey G., Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Newell, Kathy L., Ghetti, Bernardino, Goedert, Michel, Scheres, Sjors H.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472968/ https://www.ncbi.nlm.nih.gov/pubmed/30894745 http://dx.doi.org/10.1038/s41586-019-1026-5

Ejemplares similares

Structures of filaments from Pick’s disease reveal a novel tau protein fold
por: Falcon, Benjamin, et al.
Publicado: (2018)

Novel tau filament fold in corticobasal degeneration
por: Zhang, Wenjuan, et al.
Publicado: (2020)

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold
por: Falcon, Benjamin, et al.
Publicado: (2018)

Cryo-EM structures of Tau filaments from Alzheimer’s disease brain
por: Fitzpatrick, Anthony W.P., et al.
Publicado: (2017)

Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir
por: Shi, Yang, et al.
Publicado: (2023)

Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy
por: Yang, Yang, et al.
Publicado: (2023)

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
por: Zhang, Wenjuan, et al.
Publicado: (2019)

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
por: Shi, Yang, et al.
Publicado: (2021)

Correction to: Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
por: Shi, Yang, et al.
Publicado: (2021)

Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy
por: Lövestam, Sofia, et al.
Publicado: (2022)

TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP
por: Arseni, Diana, et al.
Publicado: (2023)

Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
por: Schweighauser, Manuel, et al.
Publicado: (2023)

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis
por: Zivanov, Jasenko, et al.
Publicado: (2019)

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1
por: Zivanov, Jasenko, et al.
Publicado: (2020)

Structures of α-synuclein filaments from human brains with Lewy pathology
por: Yang, Yang, et al.
Publicado: (2022)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

New tools for automated high-resolution cryo-EM structure determination in RELION-3
por: Zivanov, Jasenko, et al.
Publicado: (2018)

Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold
por: Qi, Chao, et al.
Publicado: (2023)

Age-dependent formation of TMEM106B amyloid filaments in human brains
por: Schweighauser, Manuel, et al.
Publicado: (2022)

Mutation ∆K281 in MAPT causes Pick’s disease
por: Schweighauser, Manuel, et al.
Publicado: (2023)

Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
por: Qi, Chao, et al.
Publicado: (2023)

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains
por: Yang, Yang, et al.
Publicado: (2023)

Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia
por: Brelstaff, Jack, et al.
Publicado: (2018)

Structure of Tau filaments in Prion protein amyloidoses
por: Hallinan, Grace I., et al.
Publicado: (2021)

A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0
por: Zivanov, Jasenko, et al.
Publicado: (2022)

Beam-induced motion correction for sub-megadalton cryo-EM particles
por: Scheres, Sjors HW
Publicado: (2014)

A Bayesian View on Cryo-EM Structure Determination
por: Scheres, Sjors H.W.
Publicado: (2012)

RELION: Implementation of a Bayesian approach to cryo-EM structure determination
por: Scheres, Sjors H.W.
Publicado: (2012)

Semi-automated selection of cryo-EM particles in RELION-1.3
por: Scheres, Sjors H.W.
Publicado: (2015)

Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]
por: Velasco, Ana, et al.
Publicado: (2008)

Double gallbladder completely enclosed in a cystogastric fold of peritoneum
por: Nayak, Satheesha B., et al.
Publicado: (2014)

Helical reconstruction in RELION
por: He, Shaoda, et al.
Publicado: (2017)

Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V(1) Motor of the Manduca sexta V-ATPase()
por: Muench, Stephen P., et al.
Publicado: (2014)

Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy
por: Lövestam, Sofia, et al.
Publicado: (2021)

Cross-β helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia
por: Hoq, Md. Rejaul, et al.
Publicado: (2023)

Distinguishing post‐translational modifications in dominantly inherited frontotemporal dementias: FTLD‐TDP Type A (GRN) vs Type B (C9orf72)
por: Cracco, Laura, et al.
Publicado: (2022)

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
por: Morgan, Sophie A., et al.
Publicado: (2020)

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION
por: Nakane, Takanori, et al.
Publicado: (2018)

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI(2)/Tau Transgenic Mice
por: Garringer, Holly J., et al.
Publicado: (2013)

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2
por: Kimanius, Dari, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fc3cnaqpagv031m17hr6jjb6il