Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to a...

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Autores principales: Kovina, Marina V., Karnaukhov, Alexey V., Krasheninnikov, Mikhail E., Kovin, Artem L., Gazheev, Sarul T., Sergievich, Larisa A., Karnaukhova, Elena V., Bogdanenko, Elena V., Balyasin, Maxim V., Khodarovich, Yury M., Dyuzheva, Tatyana G., Lyundup, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473025/
https://www.ncbi.nlm.nih.gov/pubmed/31031800
http://dx.doi.org/10.3389/fgene.2019.00310
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author Kovina, Marina V.
Karnaukhov, Alexey V.
Krasheninnikov, Mikhail E.
Kovin, Artem L.
Gazheev, Sarul T.
Sergievich, Larisa A.
Karnaukhova, Elena V.
Bogdanenko, Elena V.
Balyasin, Maxim V.
Khodarovich, Yury M.
Dyuzheva, Tatyana G.
Lyundup, Alexey V.
author_facet Kovina, Marina V.
Karnaukhov, Alexey V.
Krasheninnikov, Mikhail E.
Kovin, Artem L.
Gazheev, Sarul T.
Sergievich, Larisa A.
Karnaukhova, Elena V.
Bogdanenko, Elena V.
Balyasin, Maxim V.
Khodarovich, Yury M.
Dyuzheva, Tatyana G.
Lyundup, Alexey V.
author_sort Kovina, Marina V.
collection PubMed
description The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5%, and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28%.
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spelling pubmed-64730252019-04-26 Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice Kovina, Marina V. Karnaukhov, Alexey V. Krasheninnikov, Mikhail E. Kovin, Artem L. Gazheev, Sarul T. Sergievich, Larisa A. Karnaukhova, Elena V. Bogdanenko, Elena V. Balyasin, Maxim V. Khodarovich, Yury M. Dyuzheva, Tatyana G. Lyundup, Alexey V. Front Genet Genetics The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5%, and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28%. Frontiers Media S.A. 2019-04-12 /pmc/articles/PMC6473025/ /pubmed/31031800 http://dx.doi.org/10.3389/fgene.2019.00310 Text en Copyright © 2019 Kovina, Karnaukhov, Krasheninnikov, Kovin, Gazheev, Sergievich, Karnaukhova, Bogdanenko, Balyasin, Khodarovich, Dyuzheva and Lyundup. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Kovina, Marina V.
Karnaukhov, Alexey V.
Krasheninnikov, Mikhail E.
Kovin, Artem L.
Gazheev, Sarul T.
Sergievich, Larisa A.
Karnaukhova, Elena V.
Bogdanenko, Elena V.
Balyasin, Maxim V.
Khodarovich, Yury M.
Dyuzheva, Tatyana G.
Lyundup, Alexey V.
Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title_full Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title_fullStr Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title_full_unstemmed Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title_short Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice
title_sort extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old mice
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473025/
https://www.ncbi.nlm.nih.gov/pubmed/31031800
http://dx.doi.org/10.3389/fgene.2019.00310
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