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The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was ass...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473034/ https://www.ncbi.nlm.nih.gov/pubmed/31031700 http://dx.doi.org/10.3389/fneur.2019.00375 |
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author | Baik, Minyoul Kim, Seung Up Nam, Hyo Suk Heo, Ji Hoe Kim, Young Dae |
author_facet | Baik, Minyoul Kim, Seung Up Nam, Hyo Suk Heo, Ji Hoe Kim, Young Dae |
author_sort | Baik, Minyoul |
collection | PubMed |
description | Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), −39.2 to −3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. |
format | Online Article Text |
id | pubmed-6473034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64730342019-04-26 The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke Baik, Minyoul Kim, Seung Up Nam, Hyo Suk Heo, Ji Hoe Kim, Young Dae Front Neurol Neurology Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), −39.2 to −3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Frontiers Media S.A. 2019-04-12 /pmc/articles/PMC6473034/ /pubmed/31031700 http://dx.doi.org/10.3389/fneur.2019.00375 Text en Copyright © 2019 Baik, Kim, Nam, Heo and Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Baik, Minyoul Kim, Seung Up Nam, Hyo Suk Heo, Ji Hoe Kim, Young Dae The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title | The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title_full | The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title_fullStr | The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title_full_unstemmed | The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title_short | The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke |
title_sort | paradoxical protective effect of liver steatosis on severity and functional outcome of ischemic stroke |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473034/ https://www.ncbi.nlm.nih.gov/pubmed/31031700 http://dx.doi.org/10.3389/fneur.2019.00375 |
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