Cargando…

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke

Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was ass...

Descripción completa

Detalles Bibliográficos
Autores principales: Baik, Minyoul, Kim, Seung Up, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473034/
https://www.ncbi.nlm.nih.gov/pubmed/31031700
http://dx.doi.org/10.3389/fneur.2019.00375
_version_ 1783412342421192704
author Baik, Minyoul
Kim, Seung Up
Nam, Hyo Suk
Heo, Ji Hoe
Kim, Young Dae
author_facet Baik, Minyoul
Kim, Seung Up
Nam, Hyo Suk
Heo, Ji Hoe
Kim, Young Dae
author_sort Baik, Minyoul
collection PubMed
description Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), −39.2 to −3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA.
format Online
Article
Text
id pubmed-6473034
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-64730342019-04-26 The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke Baik, Minyoul Kim, Seung Up Nam, Hyo Suk Heo, Ji Hoe Kim, Young Dae Front Neurol Neurology Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patients with first-ever acute ischemic stroke or TIA, who underwent transient elastography from January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Stroke Scale (NIHSS), was investigated using robust regression analysis. We also compared the functional outcome at 90 days according to the presence or burden of liver steatosis. Results: NAFLD was observed in 206 (64.2%) patients. Patients with NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = 0.012) and more favorable functional outcome at 90 days (85.3 vs. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower [95% confidence interval (CI), −39.2 to −3.2%, P = 0.026] NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = 0.033) possibility of favorable functional outcome in multivariate analysis. Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Frontiers Media S.A. 2019-04-12 /pmc/articles/PMC6473034/ /pubmed/31031700 http://dx.doi.org/10.3389/fneur.2019.00375 Text en Copyright © 2019 Baik, Kim, Nam, Heo and Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Baik, Minyoul
Kim, Seung Up
Nam, Hyo Suk
Heo, Ji Hoe
Kim, Young Dae
The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title_full The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title_fullStr The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title_full_unstemmed The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title_short The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
title_sort paradoxical protective effect of liver steatosis on severity and functional outcome of ischemic stroke
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473034/
https://www.ncbi.nlm.nih.gov/pubmed/31031700
http://dx.doi.org/10.3389/fneur.2019.00375
work_keys_str_mv AT baikminyoul theparadoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT kimseungup theparadoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT namhyosuk theparadoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT heojihoe theparadoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT kimyoungdae theparadoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT baikminyoul paradoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT kimseungup paradoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT namhyosuk paradoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT heojihoe paradoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke
AT kimyoungdae paradoxicalprotectiveeffectofliversteatosisonseverityandfunctionaloutcomeofischemicstroke