Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines

Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor...

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Autores principales: Vatlin, Aleksey A., Shur, Kirill V., Danilenko, Valery N., Maslov, Dmitry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Genome Sequences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473147/
https://www.ncbi.nlm.nih.gov/pubmed/31000553
http://dx.doi.org/10.1128/MRA.00263-19
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author Vatlin, Aleksey A.
Shur, Kirill V.
Danilenko, Valery N.
Maslov, Dmitry A.
author_facet Vatlin, Aleksey A.
Shur, Kirill V.
Danilenko, Valery N.
Maslov, Dmitry A.
author_sort Vatlin, Aleksey A.
collection PubMed
description Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.
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spelling pubmed-64731472019-04-24 Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines Vatlin, Aleksey A. Shur, Kirill V. Danilenko, Valery N. Maslov, Dmitry A. Microbiol Resour Announc Genome Sequences Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance. American Society for Microbiology 2019-04-18 /pmc/articles/PMC6473147/ /pubmed/31000553 http://dx.doi.org/10.1128/MRA.00263-19 Text en Copyright © 2019 Vatlin et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Genome Sequences
Vatlin, Aleksey A.
Shur, Kirill V.
Danilenko, Valery N.
Maslov, Dmitry A.
Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title_full Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title_fullStr Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title_full_unstemmed Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title_short Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines
title_sort draft genome sequences of 12 mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines
topic Genome Sequences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473147/
https://www.ncbi.nlm.nih.gov/pubmed/31000553
http://dx.doi.org/10.1128/MRA.00263-19
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