Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil

In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obt...

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Autores principales: Parisi, Evelina, Garcia, Ana M., Marson, Domenico, Posocco, Paola, Marchesan, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473331/
https://www.ncbi.nlm.nih.gov/pubmed/30691142
http://dx.doi.org/10.3390/gels5010005
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author Parisi, Evelina
Garcia, Ana M.
Marson, Domenico
Posocco, Paola
Marchesan, Silvia
author_facet Parisi, Evelina
Garcia, Ana M.
Marson, Domenico
Posocco, Paola
Marchesan, Silvia
author_sort Parisi, Evelina
collection PubMed
description In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations.
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spelling pubmed-64733312019-04-29 Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil Parisi, Evelina Garcia, Ana M. Marson, Domenico Posocco, Paola Marchesan, Silvia Gels Article In this work, we present Thioflavin T fluorescence, transmission electron microscopy (TEM), circular dichroism (CD), Fourier-transformed infrared (FT-IR), and oscillatory rheometry studies applied to an antineoplastic drug, 5-fluorouracil (5-FU), embedded in a heterochiral tripeptide hydrogel to obtain a drug delivery supramolecular system. The release of 5-fluorouracil was monitored over time by reverse-phase high-performance liquid chromatography (HPLC) and its interaction with the tripeptide assemblies was probed by all-atom molecular dynamics simulations. MDPI 2019-01-26 /pmc/articles/PMC6473331/ /pubmed/30691142 http://dx.doi.org/10.3390/gels5010005 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parisi, Evelina
Garcia, Ana M.
Marson, Domenico
Posocco, Paola
Marchesan, Silvia
Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title_full Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title_fullStr Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title_full_unstemmed Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title_short Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
title_sort supramolecular tripeptide hydrogel assembly with 5-fluorouracil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473331/
https://www.ncbi.nlm.nih.gov/pubmed/30691142
http://dx.doi.org/10.3390/gels5010005
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AT posoccopaola supramoleculartripeptidehydrogelassemblywith5fluorouracil
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