A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs

This small study reports on a non-pyrogenic response of five different Australian isolates of Coxiella burnetii (C. burnetii). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guin...

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Detalles Bibliográficos
Autores principales: Islam, Aminul, Stenos, John, Vincent, Gemma, Graves, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473353/
https://www.ncbi.nlm.nih.gov/pubmed/30691029
http://dx.doi.org/10.3390/tropicalmed4010018
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author Islam, Aminul
Stenos, John
Vincent, Gemma
Graves, Stephen
author_facet Islam, Aminul
Stenos, John
Vincent, Gemma
Graves, Stephen
author_sort Islam, Aminul
collection PubMed
description This small study reports on a non-pyrogenic response of five different Australian isolates of Coxiella burnetii (C. burnetii). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guinea pigs infected with these isolates did not develop fever (temperature ≥ 40.0 °C), which is consistent with other members of this genomic group that were isolated from elsewhere in the world. In contrast, guinea pigs infected with the classical USA tick isolate, Nine Mile phase 1 (RSA 493) of Genomic Group I, experienced a four-day febrile period.
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spelling pubmed-64733532019-04-29 A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs Islam, Aminul Stenos, John Vincent, Gemma Graves, Stephen Trop Med Infect Dis Brief Report This small study reports on a non-pyrogenic response of five different Australian isolates of Coxiella burnetii (C. burnetii). They were all members of Genomic Group IV and obtained from three cases of acute human infection, one case of chronic human infection and one case of goat abortion. The guinea pigs infected with these isolates did not develop fever (temperature ≥ 40.0 °C), which is consistent with other members of this genomic group that were isolated from elsewhere in the world. In contrast, guinea pigs infected with the classical USA tick isolate, Nine Mile phase 1 (RSA 493) of Genomic Group I, experienced a four-day febrile period. MDPI 2019-01-25 /pmc/articles/PMC6473353/ /pubmed/30691029 http://dx.doi.org/10.3390/tropicalmed4010018 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Islam, Aminul
Stenos, John
Vincent, Gemma
Graves, Stephen
A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title_full A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title_fullStr A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title_full_unstemmed A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title_short A Short Report on the Lack of a Pyrogenic Response of Australian Genomic Group IV Isolates of Coxiella burnetii in Guinea Pigs
title_sort short report on the lack of a pyrogenic response of australian genomic group iv isolates of coxiella burnetii in guinea pigs
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473353/
https://www.ncbi.nlm.nih.gov/pubmed/30691029
http://dx.doi.org/10.3390/tropicalmed4010018
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