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Search for Drugs Used in Hospitals to Treat Stomatitis

Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with...

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Autores principales: Hara, Yaeko, Shiratuchi, Hiroshi, Kaneko, Tadayoshi, Sakagami, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473359/
https://www.ncbi.nlm.nih.gov/pubmed/30699927
http://dx.doi.org/10.3390/medicines6010019
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author Hara, Yaeko
Shiratuchi, Hiroshi
Kaneko, Tadayoshi
Sakagami, Hiroshi
author_facet Hara, Yaeko
Shiratuchi, Hiroshi
Kaneko, Tadayoshi
Sakagami, Hiroshi
author_sort Hara, Yaeko
collection PubMed
description Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Chemotherapy, especially in the head and neck region, induces stomatitis at higher frequency, which directly affects the patient’s quality of life and treatment schedule. However, effective treatment for stomatitis has yet to be established. This article presents the clinical report of Kampo medicines on the stomatitis patients in the Nihon university, and then reviews the literature of traditional medicines for the treatment of stomatitis. Among eighteen Kampo medicines, Hangeshashinto has been the most popular for the treatment of stomatitis, due to its prominent anti-inflammatory activity. It was unexpected that clinical data of Hangeshashinto on stomatitis from Chinese hospital are not available. Kampo medicines have been most exclusively administered to elder person, as compared to pediatric population. Supplementation of alkaline plant extracts rich in lignin-carbohydrate complex may further extend the applicability of Kampo medicines to viral diseases.
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spelling pubmed-64733592019-04-30 Search for Drugs Used in Hospitals to Treat Stomatitis Hara, Yaeko Shiratuchi, Hiroshi Kaneko, Tadayoshi Sakagami, Hiroshi Medicines (Basel) Review Stomatitis is an inflammatory disease of the oral mucosa, often accompanied by pain. Usually it is represented by aphthous stomatitis, for which treatment steroid ointment is commonly used. However, in the cases of refractory or recurrent stomatitis, traditional herbal medicines have been used with favorable therapeutic effects. Chemotherapy, especially in the head and neck region, induces stomatitis at higher frequency, which directly affects the patient’s quality of life and treatment schedule. However, effective treatment for stomatitis has yet to be established. This article presents the clinical report of Kampo medicines on the stomatitis patients in the Nihon university, and then reviews the literature of traditional medicines for the treatment of stomatitis. Among eighteen Kampo medicines, Hangeshashinto has been the most popular for the treatment of stomatitis, due to its prominent anti-inflammatory activity. It was unexpected that clinical data of Hangeshashinto on stomatitis from Chinese hospital are not available. Kampo medicines have been most exclusively administered to elder person, as compared to pediatric population. Supplementation of alkaline plant extracts rich in lignin-carbohydrate complex may further extend the applicability of Kampo medicines to viral diseases. MDPI 2019-01-29 /pmc/articles/PMC6473359/ /pubmed/30699927 http://dx.doi.org/10.3390/medicines6010019 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hara, Yaeko
Shiratuchi, Hiroshi
Kaneko, Tadayoshi
Sakagami, Hiroshi
Search for Drugs Used in Hospitals to Treat Stomatitis
title Search for Drugs Used in Hospitals to Treat Stomatitis
title_full Search for Drugs Used in Hospitals to Treat Stomatitis
title_fullStr Search for Drugs Used in Hospitals to Treat Stomatitis
title_full_unstemmed Search for Drugs Used in Hospitals to Treat Stomatitis
title_short Search for Drugs Used in Hospitals to Treat Stomatitis
title_sort search for drugs used in hospitals to treat stomatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473359/
https://www.ncbi.nlm.nih.gov/pubmed/30699927
http://dx.doi.org/10.3390/medicines6010019
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