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POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness
In order to improve the performance of traditional sodium alginate (SA) hydrogels cross-linked by Ca(2+) ions to meet greater application demand, a strategy was designed to structure novel SA-based gels (named OP-PN gels) to achieve both stimulus responsiveness and improved mechanical strength. In t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473450/ https://www.ncbi.nlm.nih.gov/pubmed/30960509 http://dx.doi.org/10.3390/polym11030524 |
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author | Chen, Yi Zhou, Yueyun Liu, Wenyong Pi, Hejie Zeng, Guangsheng |
author_facet | Chen, Yi Zhou, Yueyun Liu, Wenyong Pi, Hejie Zeng, Guangsheng |
author_sort | Chen, Yi |
collection | PubMed |
description | In order to improve the performance of traditional sodium alginate (SA) hydrogels cross-linked by Ca(2+) ions to meet greater application demand, a strategy was designed to structure novel SA-based gels (named OP-PN gels) to achieve both stimulus responsiveness and improved mechanical strength. In this strategy, the SA chains are co-cross-linked by CaCl(2) and cationic octa-ammonium polyhedral oligomeric silsesquioxane (Oa-POSS) particles as the first network, and an organically cross-linked poly(N-isopropyl acrylamide) (PNIPA) network is introduced into the gels as the second network. Several main results are obtained from the synthesis and characterization of the gels. For OP-PN gels, their properties depend on the content of both uniformly dispersed Oa-POSS and PNIPA network directly. The increased Oa-POSS and PNIPA network content significantly improves both the strength and resilience of gels. Relatively, the increased Oa-POSS is greatly beneficial to the modulus of gels, and the increased PNIPA network is more favorable to advancing the tensile deformation of gels. The gels with hydrophilic PNIPA network exhibit better swelling ability and remarkable temperature responsiveness, and their volume phase transition temperature can be adjusted by altering the content of Oa-POSS. The deswelling rate of gels increases gradually with the increase of POSS content due to the hydrophobic Si–O skeleton of POSS. Moreover, the enhanced drug loading and sustained release ability of the target drug bovine serum albumin displays great potential for this hybrid gel in the biomedical field. |
format | Online Article Text |
id | pubmed-6473450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64734502019-05-03 POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness Chen, Yi Zhou, Yueyun Liu, Wenyong Pi, Hejie Zeng, Guangsheng Polymers (Basel) Article In order to improve the performance of traditional sodium alginate (SA) hydrogels cross-linked by Ca(2+) ions to meet greater application demand, a strategy was designed to structure novel SA-based gels (named OP-PN gels) to achieve both stimulus responsiveness and improved mechanical strength. In this strategy, the SA chains are co-cross-linked by CaCl(2) and cationic octa-ammonium polyhedral oligomeric silsesquioxane (Oa-POSS) particles as the first network, and an organically cross-linked poly(N-isopropyl acrylamide) (PNIPA) network is introduced into the gels as the second network. Several main results are obtained from the synthesis and characterization of the gels. For OP-PN gels, their properties depend on the content of both uniformly dispersed Oa-POSS and PNIPA network directly. The increased Oa-POSS and PNIPA network content significantly improves both the strength and resilience of gels. Relatively, the increased Oa-POSS is greatly beneficial to the modulus of gels, and the increased PNIPA network is more favorable to advancing the tensile deformation of gels. The gels with hydrophilic PNIPA network exhibit better swelling ability and remarkable temperature responsiveness, and their volume phase transition temperature can be adjusted by altering the content of Oa-POSS. The deswelling rate of gels increases gradually with the increase of POSS content due to the hydrophobic Si–O skeleton of POSS. Moreover, the enhanced drug loading and sustained release ability of the target drug bovine serum albumin displays great potential for this hybrid gel in the biomedical field. MDPI 2019-03-20 /pmc/articles/PMC6473450/ /pubmed/30960509 http://dx.doi.org/10.3390/polym11030524 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Yi Zhou, Yueyun Liu, Wenyong Pi, Hejie Zeng, Guangsheng POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title | POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title_full | POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title_fullStr | POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title_full_unstemmed | POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title_short | POSS Hybrid Robust Biomass IPN Hydrogels with Temperature Responsiveness |
title_sort | poss hybrid robust biomass ipn hydrogels with temperature responsiveness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473450/ https://www.ncbi.nlm.nih.gov/pubmed/30960509 http://dx.doi.org/10.3390/polym11030524 |
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