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Clostridium difficile in Asia: Opportunities for One Health Management

Clostridium difficile is a ubiquitous spore-forming bacterium which causes toxin-mediated diarrhoea and colitis in people whose gut microflora has been depleted by antimicrobial use, so it is a predominantly healthcare-associated disease. However, there are many One Health implications to C. diffici...

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Autores principales: Collins, Deirdre A., Riley, Thomas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473466/
https://www.ncbi.nlm.nih.gov/pubmed/30597880
http://dx.doi.org/10.3390/tropicalmed4010007
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author Collins, Deirdre A.
Riley, Thomas V.
author_facet Collins, Deirdre A.
Riley, Thomas V.
author_sort Collins, Deirdre A.
collection PubMed
description Clostridium difficile is a ubiquitous spore-forming bacterium which causes toxin-mediated diarrhoea and colitis in people whose gut microflora has been depleted by antimicrobial use, so it is a predominantly healthcare-associated disease. However, there are many One Health implications to C. difficile, given high colonisation rates in food production animals, contamination of outdoor environments by use of contaminated animal manure, increasing incidence of community-associated C. difficile infection (CDI), and demonstration of clonal groups of C. difficile shared between human clinical cases and food animals. In Asia, the epidemiology of CDI is not well understood given poor testing practices in many countries. The growing middle-class populations of Asia are presenting increasing demands for meat, thus production farming, particularly of pigs, chicken and cattle, is rapidly expanding in Asian countries. Few reports on C. difficile colonisation among production animals in Asia exist, but those that do show high prevalence rates, and possible importation of European strains of C. difficile like ribotype 078. This review summarises our current understanding of the One Health aspects of the epidemiology of CDI in Asia.
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spelling pubmed-64734662019-04-29 Clostridium difficile in Asia: Opportunities for One Health Management Collins, Deirdre A. Riley, Thomas V. Trop Med Infect Dis Review Clostridium difficile is a ubiquitous spore-forming bacterium which causes toxin-mediated diarrhoea and colitis in people whose gut microflora has been depleted by antimicrobial use, so it is a predominantly healthcare-associated disease. However, there are many One Health implications to C. difficile, given high colonisation rates in food production animals, contamination of outdoor environments by use of contaminated animal manure, increasing incidence of community-associated C. difficile infection (CDI), and demonstration of clonal groups of C. difficile shared between human clinical cases and food animals. In Asia, the epidemiology of CDI is not well understood given poor testing practices in many countries. The growing middle-class populations of Asia are presenting increasing demands for meat, thus production farming, particularly of pigs, chicken and cattle, is rapidly expanding in Asian countries. Few reports on C. difficile colonisation among production animals in Asia exist, but those that do show high prevalence rates, and possible importation of European strains of C. difficile like ribotype 078. This review summarises our current understanding of the One Health aspects of the epidemiology of CDI in Asia. MDPI 2018-12-28 /pmc/articles/PMC6473466/ /pubmed/30597880 http://dx.doi.org/10.3390/tropicalmed4010007 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Collins, Deirdre A.
Riley, Thomas V.
Clostridium difficile in Asia: Opportunities for One Health Management
title Clostridium difficile in Asia: Opportunities for One Health Management
title_full Clostridium difficile in Asia: Opportunities for One Health Management
title_fullStr Clostridium difficile in Asia: Opportunities for One Health Management
title_full_unstemmed Clostridium difficile in Asia: Opportunities for One Health Management
title_short Clostridium difficile in Asia: Opportunities for One Health Management
title_sort clostridium difficile in asia: opportunities for one health management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473466/
https://www.ncbi.nlm.nih.gov/pubmed/30597880
http://dx.doi.org/10.3390/tropicalmed4010007
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