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Generational Health Impact of PCOS on Women and Their Children

Polycystic ovary syndrome (PCOS) is a metabolic disorder with reproductive consequences. Hence, the synergy of the dual maternal challenges of difficulties with conception, set on a background of metabolic disorder and inflammation, understandably leads to increased obstetric risk for the woman. Fur...

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Detalles Bibliográficos
Autor principal: Hart, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473601/
https://www.ncbi.nlm.nih.gov/pubmed/30889922
http://dx.doi.org/10.3390/medsci7030049
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author Hart, Roger
author_facet Hart, Roger
author_sort Hart, Roger
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description Polycystic ovary syndrome (PCOS) is a metabolic disorder with reproductive consequences. Hence, the synergy of the dual maternal challenges of difficulties with conception, set on a background of metabolic disorder and inflammation, understandably leads to increased obstetric risk for the woman. Furthermore, she is more likely than her peers to require assistance with conception, either through induction of ovulation with the attendant risk of a multiple gestation, or in vitro fertilization (IVF) with its recognized increased obstetric risk for woman and her child. The increased obstetric risk for a woman with PCOS is manifested with an increased rate of miscarriage, gestational diabetes, hypertensive disorder and premature delivery. These obstetric complications are due to impairment of placental function, systemic inflammation and metabolic disorder and are markers for the woman herself of her predisposition to cardiometabolic disorder in later life. Consequently, it is inevitable that this environment may induce changes in the fetus during pregnancy, leading to an intergenerational risk from maternal PCOS.
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spelling pubmed-64736012019-04-29 Generational Health Impact of PCOS on Women and Their Children Hart, Roger Med Sci (Basel) Review Polycystic ovary syndrome (PCOS) is a metabolic disorder with reproductive consequences. Hence, the synergy of the dual maternal challenges of difficulties with conception, set on a background of metabolic disorder and inflammation, understandably leads to increased obstetric risk for the woman. Furthermore, she is more likely than her peers to require assistance with conception, either through induction of ovulation with the attendant risk of a multiple gestation, or in vitro fertilization (IVF) with its recognized increased obstetric risk for woman and her child. The increased obstetric risk for a woman with PCOS is manifested with an increased rate of miscarriage, gestational diabetes, hypertensive disorder and premature delivery. These obstetric complications are due to impairment of placental function, systemic inflammation and metabolic disorder and are markers for the woman herself of her predisposition to cardiometabolic disorder in later life. Consequently, it is inevitable that this environment may induce changes in the fetus during pregnancy, leading to an intergenerational risk from maternal PCOS. MDPI 2019-03-18 /pmc/articles/PMC6473601/ /pubmed/30889922 http://dx.doi.org/10.3390/medsci7030049 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hart, Roger
Generational Health Impact of PCOS on Women and Their Children
title Generational Health Impact of PCOS on Women and Their Children
title_full Generational Health Impact of PCOS on Women and Their Children
title_fullStr Generational Health Impact of PCOS on Women and Their Children
title_full_unstemmed Generational Health Impact of PCOS on Women and Their Children
title_short Generational Health Impact of PCOS on Women and Their Children
title_sort generational health impact of pcos on women and their children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473601/
https://www.ncbi.nlm.nih.gov/pubmed/30889922
http://dx.doi.org/10.3390/medsci7030049
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