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Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473657/ https://www.ncbi.nlm.nih.gov/pubmed/30591622 http://dx.doi.org/10.3390/tropicalmed4010006 |
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author | Araujo, Tiago Katiyar, Vatsala Gonzales Zamora, Jose A. |
author_facet | Araujo, Tiago Katiyar, Vatsala Gonzales Zamora, Jose A. |
author_sort | Araujo, Tiago |
collection | PubMed |
description | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induced hemolytic events in G6PD-deficient patients has rarely been reported. Despite an estimated overall prevalence of 6.8%–13% of this disorder in the HIV population, clinically significant hemolysis has been largely attributed to the use of offending medications rather than HIV infection itself. Here, we present a patient whose first episode of G6PD deficiency-associated hemolysis occurred as the main presentation of acute HIV infection. |
format | Online Article Text |
id | pubmed-6473657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64736572019-04-29 Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency Araujo, Tiago Katiyar, Vatsala Gonzales Zamora, Jose A. Trop Med Infect Dis Case Report Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induced hemolytic events in G6PD-deficient patients has rarely been reported. Despite an estimated overall prevalence of 6.8%–13% of this disorder in the HIV population, clinically significant hemolysis has been largely attributed to the use of offending medications rather than HIV infection itself. Here, we present a patient whose first episode of G6PD deficiency-associated hemolysis occurred as the main presentation of acute HIV infection. MDPI 2018-12-27 /pmc/articles/PMC6473657/ /pubmed/30591622 http://dx.doi.org/10.3390/tropicalmed4010006 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Araujo, Tiago Katiyar, Vatsala Gonzales Zamora, Jose A. Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title | Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title_full | Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title_fullStr | Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title_full_unstemmed | Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title_short | Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency |
title_sort | acute retroviral syndrome presenting with hemolytic anemia induced by g6pd deficiency |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473657/ https://www.ncbi.nlm.nih.gov/pubmed/30591622 http://dx.doi.org/10.3390/tropicalmed4010006 |
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