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Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induc...

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Autores principales: Araujo, Tiago, Katiyar, Vatsala, Gonzales Zamora, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473657/
https://www.ncbi.nlm.nih.gov/pubmed/30591622
http://dx.doi.org/10.3390/tropicalmed4010006
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author Araujo, Tiago
Katiyar, Vatsala
Gonzales Zamora, Jose A.
author_facet Araujo, Tiago
Katiyar, Vatsala
Gonzales Zamora, Jose A.
author_sort Araujo, Tiago
collection PubMed
description Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induced hemolytic events in G6PD-deficient patients has rarely been reported. Despite an estimated overall prevalence of 6.8%–13% of this disorder in the HIV population, clinically significant hemolysis has been largely attributed to the use of offending medications rather than HIV infection itself. Here, we present a patient whose first episode of G6PD deficiency-associated hemolysis occurred as the main presentation of acute HIV infection.
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spelling pubmed-64736572019-04-29 Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency Araujo, Tiago Katiyar, Vatsala Gonzales Zamora, Jose A. Trop Med Infect Dis Case Report Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect described in humans. Hemolysis in affected patients is usually triggered by circumstances involving free radical damage. While acute HIV infection is known to be a state of overwhelming oxidative stress, virus-induced hemolytic events in G6PD-deficient patients has rarely been reported. Despite an estimated overall prevalence of 6.8%–13% of this disorder in the HIV population, clinically significant hemolysis has been largely attributed to the use of offending medications rather than HIV infection itself. Here, we present a patient whose first episode of G6PD deficiency-associated hemolysis occurred as the main presentation of acute HIV infection. MDPI 2018-12-27 /pmc/articles/PMC6473657/ /pubmed/30591622 http://dx.doi.org/10.3390/tropicalmed4010006 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Araujo, Tiago
Katiyar, Vatsala
Gonzales Zamora, Jose A.
Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title_full Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title_fullStr Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title_full_unstemmed Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title_short Acute Retroviral Syndrome Presenting with Hemolytic Anemia Induced by G6PD Deficiency
title_sort acute retroviral syndrome presenting with hemolytic anemia induced by g6pd deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473657/
https://www.ncbi.nlm.nih.gov/pubmed/30591622
http://dx.doi.org/10.3390/tropicalmed4010006
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