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Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473879/ https://www.ncbi.nlm.nih.gov/pubmed/30845674 http://dx.doi.org/10.3390/gels5010014 |
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author | Rivas, Manuel del Valle, Luís J. Alemán, Carlos Puiggalí, Jordi |
author_facet | Rivas, Manuel del Valle, Luís J. Alemán, Carlos Puiggalí, Jordi |
author_sort | Rivas, Manuel |
collection | PubMed |
description | Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrogels can mimic the extracellular matrix and favor the growth of hydroxyapatite (HAp) as well as its encapsulation. Newly designed materials offer great perspectives for applications in the regeneration of hard tissues such as bones, teeth, and cartilage. Furthermore, development of drug delivery systems based on HAp and peptide self-assembly is attracting attention. |
format | Online Article Text |
id | pubmed-6473879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64738792019-04-29 Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite Rivas, Manuel del Valle, Luís J. Alemán, Carlos Puiggalí, Jordi Gels Review Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrogels can mimic the extracellular matrix and favor the growth of hydroxyapatite (HAp) as well as its encapsulation. Newly designed materials offer great perspectives for applications in the regeneration of hard tissues such as bones, teeth, and cartilage. Furthermore, development of drug delivery systems based on HAp and peptide self-assembly is attracting attention. MDPI 2019-03-06 /pmc/articles/PMC6473879/ /pubmed/30845674 http://dx.doi.org/10.3390/gels5010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rivas, Manuel del Valle, Luís J. Alemán, Carlos Puiggalí, Jordi Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title | Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title_full | Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title_fullStr | Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title_full_unstemmed | Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title_short | Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite |
title_sort | peptide self-assembly into hydrogels for biomedical applications related to hydroxyapatite |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473879/ https://www.ncbi.nlm.nih.gov/pubmed/30845674 http://dx.doi.org/10.3390/gels5010014 |
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