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Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite

Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrog...

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Detalles Bibliográficos
Autores principales: Rivas, Manuel, del Valle, Luís J., Alemán, Carlos, Puiggalí, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473879/
https://www.ncbi.nlm.nih.gov/pubmed/30845674
http://dx.doi.org/10.3390/gels5010014
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author Rivas, Manuel
del Valle, Luís J.
Alemán, Carlos
Puiggalí, Jordi
author_facet Rivas, Manuel
del Valle, Luís J.
Alemán, Carlos
Puiggalí, Jordi
author_sort Rivas, Manuel
collection PubMed
description Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrogels can mimic the extracellular matrix and favor the growth of hydroxyapatite (HAp) as well as its encapsulation. Newly designed materials offer great perspectives for applications in the regeneration of hard tissues such as bones, teeth, and cartilage. Furthermore, development of drug delivery systems based on HAp and peptide self-assembly is attracting attention.
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spelling pubmed-64738792019-04-29 Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite Rivas, Manuel del Valle, Luís J. Alemán, Carlos Puiggalí, Jordi Gels Review Amphiphilic peptides can be self-assembled by establishing physical cross-links involving hydrogen bonds and electrostatic interactions with divalent ions. The derived hydrogels have promising properties due to their biocompatibility, reversibility, trigger capability, and tunability. Peptide hydrogels can mimic the extracellular matrix and favor the growth of hydroxyapatite (HAp) as well as its encapsulation. Newly designed materials offer great perspectives for applications in the regeneration of hard tissues such as bones, teeth, and cartilage. Furthermore, development of drug delivery systems based on HAp and peptide self-assembly is attracting attention. MDPI 2019-03-06 /pmc/articles/PMC6473879/ /pubmed/30845674 http://dx.doi.org/10.3390/gels5010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rivas, Manuel
del Valle, Luís J.
Alemán, Carlos
Puiggalí, Jordi
Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title_full Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title_fullStr Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title_full_unstemmed Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title_short Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite
title_sort peptide self-assembly into hydrogels for biomedical applications related to hydroxyapatite
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473879/
https://www.ncbi.nlm.nih.gov/pubmed/30845674
http://dx.doi.org/10.3390/gels5010014
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