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Psychological Wellbeing and Healthy Aging: Focus on Telomeres
Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ‘‘accelerated aging” phenotype, as well as the incidence of age-related diseases, including...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473912/ https://www.ncbi.nlm.nih.gov/pubmed/31023993 http://dx.doi.org/10.3390/geriatrics4010025 |
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author | Boccardi, Mariangela Boccardi, Virginia |
author_facet | Boccardi, Mariangela Boccardi, Virginia |
author_sort | Boccardi, Mariangela |
collection | PubMed |
description | Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ‘‘accelerated aging” phenotype, as well as the incidence of age-related diseases, including metabolic disorders and dementia. Basic studies support the notion that the telomere and telomerase system plays a pivotal role in the aging process and disease promotion. Interestingly, short and dysfunctional telomeres are associated with reduced lifespan, as shown in animal models. In this context, telomeres are very sensitive to stress, mindset, and lifestyle, and their rescue may be sufficient to restore cell and organism viability. This mini-review discusses conceptual models of healthy and active aging and their relationship with telomere biology and mental health. |
format | Online Article Text |
id | pubmed-6473912 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64739122019-05-02 Psychological Wellbeing and Healthy Aging: Focus on Telomeres Boccardi, Mariangela Boccardi, Virginia Geriatrics (Basel) Review Stress and depression are known to modulate the aging process, and might also affect telomere biology. In fact, exposure to some biochemical pathways involved in stress-related depression may contribute to an ‘‘accelerated aging” phenotype, as well as the incidence of age-related diseases, including metabolic disorders and dementia. Basic studies support the notion that the telomere and telomerase system plays a pivotal role in the aging process and disease promotion. Interestingly, short and dysfunctional telomeres are associated with reduced lifespan, as shown in animal models. In this context, telomeres are very sensitive to stress, mindset, and lifestyle, and their rescue may be sufficient to restore cell and organism viability. This mini-review discusses conceptual models of healthy and active aging and their relationship with telomere biology and mental health. MDPI 2019-02-23 /pmc/articles/PMC6473912/ /pubmed/31023993 http://dx.doi.org/10.3390/geriatrics4010025 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boccardi, Mariangela Boccardi, Virginia Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title | Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title_full | Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title_fullStr | Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title_full_unstemmed | Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title_short | Psychological Wellbeing and Healthy Aging: Focus on Telomeres |
title_sort | psychological wellbeing and healthy aging: focus on telomeres |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473912/ https://www.ncbi.nlm.nih.gov/pubmed/31023993 http://dx.doi.org/10.3390/geriatrics4010025 |
work_keys_str_mv | AT boccardimariangela psychologicalwellbeingandhealthyagingfocusontelomeres AT boccardivirginia psychologicalwellbeingandhealthyagingfocusontelomeres |