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Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474023/ https://www.ncbi.nlm.nih.gov/pubmed/30841524 http://dx.doi.org/10.3390/nano9030367 |
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author | Yin, Chuan Rozet, Sélène Okamoto, Rino Kondo, Mikihisa Tamada, Yasushi Tanaka, Toshihisa Hattori, Hatsuhiko Tanaka, Masaki Sato, Hiromasa Iino, Shota |
author_facet | Yin, Chuan Rozet, Sélène Okamoto, Rino Kondo, Mikihisa Tamada, Yasushi Tanaka, Toshihisa Hattori, Hatsuhiko Tanaka, Masaki Sato, Hiromasa Iino, Shota |
author_sort | Yin, Chuan |
collection | PubMed |
description | In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility. |
format | Online Article Text |
id | pubmed-6474023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64740232019-05-03 Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films Yin, Chuan Rozet, Sélène Okamoto, Rino Kondo, Mikihisa Tamada, Yasushi Tanaka, Toshihisa Hattori, Hatsuhiko Tanaka, Masaki Sato, Hiromasa Iino, Shota Nanomaterials (Basel) Article In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility. MDPI 2019-03-05 /pmc/articles/PMC6474023/ /pubmed/30841524 http://dx.doi.org/10.3390/nano9030367 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yin, Chuan Rozet, Sélène Okamoto, Rino Kondo, Mikihisa Tamada, Yasushi Tanaka, Toshihisa Hattori, Hatsuhiko Tanaka, Masaki Sato, Hiromasa Iino, Shota Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title | Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title_full | Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title_fullStr | Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title_full_unstemmed | Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title_short | Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films |
title_sort | physical properties and in vitro biocompatible evaluation of silicone-modified polyurethane nanofibers and films |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474023/ https://www.ncbi.nlm.nih.gov/pubmed/30841524 http://dx.doi.org/10.3390/nano9030367 |
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