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Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films

In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s m...

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Autores principales: Yin, Chuan, Rozet, Sélène, Okamoto, Rino, Kondo, Mikihisa, Tamada, Yasushi, Tanaka, Toshihisa, Hattori, Hatsuhiko, Tanaka, Masaki, Sato, Hiromasa, Iino, Shota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474023/
https://www.ncbi.nlm.nih.gov/pubmed/30841524
http://dx.doi.org/10.3390/nano9030367
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author Yin, Chuan
Rozet, Sélène
Okamoto, Rino
Kondo, Mikihisa
Tamada, Yasushi
Tanaka, Toshihisa
Hattori, Hatsuhiko
Tanaka, Masaki
Sato, Hiromasa
Iino, Shota
author_facet Yin, Chuan
Rozet, Sélène
Okamoto, Rino
Kondo, Mikihisa
Tamada, Yasushi
Tanaka, Toshihisa
Hattori, Hatsuhiko
Tanaka, Masaki
Sato, Hiromasa
Iino, Shota
author_sort Yin, Chuan
collection PubMed
description In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility.
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spelling pubmed-64740232019-05-03 Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films Yin, Chuan Rozet, Sélène Okamoto, Rino Kondo, Mikihisa Tamada, Yasushi Tanaka, Toshihisa Hattori, Hatsuhiko Tanaka, Masaki Sato, Hiromasa Iino, Shota Nanomaterials (Basel) Article In this study, the physical properties and the biocompatibility of electrospun silicone-modified polyurethane (PUSX) nanofibers were discussed and compared with PUSX films. To investigate the effects of different structures on the physical properties, tensile strength, elongation at break, Young’s modulus, water retention, water contact angle (WCA) and thermal conductivity measurements were performed. To prove the in vitro biocompatibility of the materials, cell adhesion, cell proliferation, and cytotoxicity were studied by NIH3T3 mouse embryonic fibroblasts cells following by lactate dehydrogenase (LDH) analysis. As a conclusion, the mechanical properties, water retention, and WCA were proven to be able to be controlled and improved by adjusting the structure of PUSX. A higher hydrophobicity and lower thermal conductivity were found in PUSX nanofibers compared with polyurethane (PU) nanofibers and films. An in vitro biocompatibility evaluation shows that the cell proliferation can be performed on both PUSX nanofibers and films. However, within a short period, cells prefer to attach and entangle on PUSX nanofibers rather than PUSX films. PUSX nanofibers were proven to be a nontoxic alternative for PU nano-membranes or films in the biomedical field, because of the controllable physical properties and the biocompatibility. MDPI 2019-03-05 /pmc/articles/PMC6474023/ /pubmed/30841524 http://dx.doi.org/10.3390/nano9030367 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yin, Chuan
Rozet, Sélène
Okamoto, Rino
Kondo, Mikihisa
Tamada, Yasushi
Tanaka, Toshihisa
Hattori, Hatsuhiko
Tanaka, Masaki
Sato, Hiromasa
Iino, Shota
Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title_full Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title_fullStr Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title_full_unstemmed Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title_short Physical Properties and In Vitro Biocompatible Evaluation of Silicone-Modified Polyurethane Nanofibers and Films
title_sort physical properties and in vitro biocompatible evaluation of silicone-modified polyurethane nanofibers and films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474023/
https://www.ncbi.nlm.nih.gov/pubmed/30841524
http://dx.doi.org/10.3390/nano9030367
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