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How rapid advances in imaging are defining the future of precision radiation oncology

Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques—including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The op...

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Autores principales: Beaton, Laura, Bandula, Steve, Gaze, Mark N., Sharma, Ricky A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474267/
https://www.ncbi.nlm.nih.gov/pubmed/30911090
http://dx.doi.org/10.1038/s41416-019-0412-y
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author Beaton, Laura
Bandula, Steve
Gaze, Mark N.
Sharma, Ricky A.
author_facet Beaton, Laura
Bandula, Steve
Gaze, Mark N.
Sharma, Ricky A.
author_sort Beaton, Laura
collection PubMed
description Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques—including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imaging might enable higher doses of radiation to be delivered to the tumour, while sparing normal surrounding tissues. In this article, we review how the integration of existing and novel forms of computed tomography, magnetic resonance imaging and positron emission tomography have transformed tumour delineation in the radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy. Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for biologically focussed dose escalation. The rapidly evolving concept of adaptive radiotherapy, including artificial intelligence, requires imaging during treatment to be used to modify radiotherapy on a daily basis. These advances have the potential to improve clinical outcomes and reduce radiation-related long-term toxicities. We outline how recent technological advances in both imaging and radiotherapy delivery can be combined to shape the future of precision radiation oncology.
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spelling pubmed-64742672020-03-26 How rapid advances in imaging are defining the future of precision radiation oncology Beaton, Laura Bandula, Steve Gaze, Mark N. Sharma, Ricky A. Br J Cancer Review Article Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques—including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imaging might enable higher doses of radiation to be delivered to the tumour, while sparing normal surrounding tissues. In this article, we review how the integration of existing and novel forms of computed tomography, magnetic resonance imaging and positron emission tomography have transformed tumour delineation in the radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy. Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for biologically focussed dose escalation. The rapidly evolving concept of adaptive radiotherapy, including artificial intelligence, requires imaging during treatment to be used to modify radiotherapy on a daily basis. These advances have the potential to improve clinical outcomes and reduce radiation-related long-term toxicities. We outline how recent technological advances in both imaging and radiotherapy delivery can be combined to shape the future of precision radiation oncology. Nature Publishing Group UK 2019-03-26 2019-04-16 /pmc/articles/PMC6474267/ /pubmed/30911090 http://dx.doi.org/10.1038/s41416-019-0412-y Text en © Cancer Research UK 2019 https://creativecommons.org/licenses/by/4.0/This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
spellingShingle Review Article
Beaton, Laura
Bandula, Steve
Gaze, Mark N.
Sharma, Ricky A.
How rapid advances in imaging are defining the future of precision radiation oncology
title How rapid advances in imaging are defining the future of precision radiation oncology
title_full How rapid advances in imaging are defining the future of precision radiation oncology
title_fullStr How rapid advances in imaging are defining the future of precision radiation oncology
title_full_unstemmed How rapid advances in imaging are defining the future of precision radiation oncology
title_short How rapid advances in imaging are defining the future of precision radiation oncology
title_sort how rapid advances in imaging are defining the future of precision radiation oncology
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474267/
https://www.ncbi.nlm.nih.gov/pubmed/30911090
http://dx.doi.org/10.1038/s41416-019-0412-y
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