Revisiting immune escape in colorectal cancer in the era of immunotherapy

In colorectal cancer (CRC), T-cell checkpoint blockade is only effective in patients diagnosed with mismatch repair-deficient (MMR-d) cancers. However, defects in Human Leukocyte Antigen (HLA) class I expression were reported to occur in most MMR-d CRCs, which would preclude antigen presentation in...

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Detalles Bibliográficos
Autores principales: Ijsselsteijn, Marieke Erica, Petitprez, Florent, Lacroix, Laetitia, Ruano, Dina, van der Breggen, Ruud, Julie, Catherine, Morreau, Hans, Sautès-Fridman, Catherine, Fridman, Wolf Herman, de Miranda, Noel Filipe da Cunha Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474276/
https://www.ncbi.nlm.nih.gov/pubmed/30862951
http://dx.doi.org/10.1038/s41416-019-0421-x

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