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Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All

Dendritic cells (DC) fulfill an essential sentinel function within the immune system, acting at the interface of innate and adaptive immunity. The DC family, both in mouse and man, shows high functional heterogeneity in order to orchestrate immune responses toward the immense variety of pathogens an...

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Autores principales: Backer, Ronald A., Diener, Nathalie, Clausen, Björn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474365/
https://www.ncbi.nlm.nih.gov/pubmed/31031751
http://dx.doi.org/10.3389/fimmu.2019.00741
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author Backer, Ronald A.
Diener, Nathalie
Clausen, Björn E.
author_facet Backer, Ronald A.
Diener, Nathalie
Clausen, Björn E.
author_sort Backer, Ronald A.
collection PubMed
description Dendritic cells (DC) fulfill an essential sentinel function within the immune system, acting at the interface of innate and adaptive immunity. The DC family, both in mouse and man, shows high functional heterogeneity in order to orchestrate immune responses toward the immense variety of pathogens and other immunological threats. In this review, we focus on the Langerin(+)CD8(+) DC subpopulation in the spleen. Langerin(+)CD8(+) DC exhibit a high ability to take up apoptotic/dying cells, and therefore they are essential to prime and shape CD8(+) T cell responses. Next to the induction of immunity toward blood-borne pathogens, i.e., viruses, these DC are important for the regulation of tolerance toward cell-associated self-antigens. The ontogeny and differentiation pathways of CD8(+)CD103(+) DC should be further explored to better understand the immunological role of these cells as a prerequisite of their therapeutic application.
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spelling pubmed-64743652019-04-26 Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All Backer, Ronald A. Diener, Nathalie Clausen, Björn E. Front Immunol Immunology Dendritic cells (DC) fulfill an essential sentinel function within the immune system, acting at the interface of innate and adaptive immunity. The DC family, both in mouse and man, shows high functional heterogeneity in order to orchestrate immune responses toward the immense variety of pathogens and other immunological threats. In this review, we focus on the Langerin(+)CD8(+) DC subpopulation in the spleen. Langerin(+)CD8(+) DC exhibit a high ability to take up apoptotic/dying cells, and therefore they are essential to prime and shape CD8(+) T cell responses. Next to the induction of immunity toward blood-borne pathogens, i.e., viruses, these DC are important for the regulation of tolerance toward cell-associated self-antigens. The ontogeny and differentiation pathways of CD8(+)CD103(+) DC should be further explored to better understand the immunological role of these cells as a prerequisite of their therapeutic application. Frontiers Media S.A. 2019-04-12 /pmc/articles/PMC6474365/ /pubmed/31031751 http://dx.doi.org/10.3389/fimmu.2019.00741 Text en Copyright © 2019 Backer, Diener and Clausen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Backer, Ronald A.
Diener, Nathalie
Clausen, Björn E.
Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title_full Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title_fullStr Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title_full_unstemmed Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title_short Langerin(+)CD8(+) Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All
title_sort langerin(+)cd8(+) dendritic cells in the splenic marginal zone: not so marginal after all
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474365/
https://www.ncbi.nlm.nih.gov/pubmed/31031751
http://dx.doi.org/10.3389/fimmu.2019.00741
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