Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury

Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological d...

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Autores principales: Wang, Xizhi, Botchway, Benson O. A., Zhang, Yong, Yuan, Jiaying, Liu, Xuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474389/
https://www.ncbi.nlm.nih.gov/pubmed/31031590
http://dx.doi.org/10.3389/fnmol.2019.00081
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author Wang, Xizhi
Botchway, Benson O. A.
Zhang, Yong
Yuan, Jiaying
Liu, Xuehong
author_facet Wang, Xizhi
Botchway, Benson O. A.
Zhang, Yong
Yuan, Jiaying
Liu, Xuehong
author_sort Wang, Xizhi
collection PubMed
description Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been reported. Bioscaffolds can reconnect lesion gaps as well as transport cells and bioactive factors, which in turn can improve axonal and functional regeneration. Herein, we explicate the respective roles of bioscaffolds and exosomes in SCI, and elucidate on the usage of combinational therapy involving bioscaffolds and extracellular vesicles (EVs) in improving SCI.
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spelling pubmed-64743892019-04-26 Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury Wang, Xizhi Botchway, Benson O. A. Zhang, Yong Yuan, Jiaying Liu, Xuehong Front Mol Neurosci Neuroscience Spinal cord injury (SCI) can result in an irreversible disability due to loss of sensorimotor function below the lesion. Presently, clinical treatments for SCI mainly include surgery, drugs and postoperative rehabilitation. The prospective roles of bioscaffolds and exosomes in several neurological diseases have been reported. Bioscaffolds can reconnect lesion gaps as well as transport cells and bioactive factors, which in turn can improve axonal and functional regeneration. Herein, we explicate the respective roles of bioscaffolds and exosomes in SCI, and elucidate on the usage of combinational therapy involving bioscaffolds and extracellular vesicles (EVs) in improving SCI. Frontiers Media S.A. 2019-04-12 /pmc/articles/PMC6474389/ /pubmed/31031590 http://dx.doi.org/10.3389/fnmol.2019.00081 Text en Copyright © 2019 Wang, Botchway, Zhang, Yuan and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Xizhi
Botchway, Benson O. A.
Zhang, Yong
Yuan, Jiaying
Liu, Xuehong
Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title_full Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title_fullStr Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title_full_unstemmed Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title_short Combinational Treatment of Bioscaffolds and Extracellular Vesicles in Spinal Cord Injury
title_sort combinational treatment of bioscaffolds and extracellular vesicles in spinal cord injury
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474389/
https://www.ncbi.nlm.nih.gov/pubmed/31031590
http://dx.doi.org/10.3389/fnmol.2019.00081
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