Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease

Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity...

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Detalles Bibliográficos
Autores principales: Reisdorf, William C., Xie, Qing, Zeng, Xin, Xie, Wensheng, Rajpal, Neetu, Hoang, Bao, Burgert, Mark E., Kumar, Vinod, Hurle, Mark R., Rajpal, Deepak K., O’Donnell, Sarah, MacDonald, Thomas T., Vossenkämper, Anna, Wang, Lin, Reilly, Mike, Votta, Bart J., Sanchez, Yolanda, Agarwal, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474586/
https://www.ncbi.nlm.nih.gov/pubmed/31002701
http://dx.doi.org/10.1371/journal.pone.0215033

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