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Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women

BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in...

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Autores principales: Anabire, Nsoh Godwin, Aryee, Paul Armah, Abdul-Karim, Abass, Quaye, Osbourne, Awandare, Gordon Akanzuwine, Helegbe, Gideon Kofi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474591/
https://www.ncbi.nlm.nih.gov/pubmed/31002731
http://dx.doi.org/10.1371/journal.pone.0215550
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author Anabire, Nsoh Godwin
Aryee, Paul Armah
Abdul-Karim, Abass
Quaye, Osbourne
Awandare, Gordon Akanzuwine
Helegbe, Gideon Kofi
author_facet Anabire, Nsoh Godwin
Aryee, Paul Armah
Abdul-Karim, Abass
Quaye, Osbourne
Awandare, Gordon Akanzuwine
Helegbe, Gideon Kofi
author_sort Anabire, Nsoh Godwin
collection PubMed
description BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana. METHODS: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). RESULTS: Women with Malaria+CHB maintained appreciably normal hemoglobin levels (mean±SEM = 10.3±0.3 g/dL). That notwithstanding, Liver function test showed significantly elevated levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin [P<0.001 for all comparisons]. Similarly, the Malaria+CHB group had significantly elevated pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 [P<0.05 for all comparisons]. In women with Malaria+CHB, correlation analysis showed significant negative association of the pro-inflammatory cytokines responses with malaria parasitemia [IL-1β (P<0.001; r = -0.645), IL-6 (P = 0.046; r = -0.394) and IL-12 (P = 0.011; r = -0.49)]. On the other hand, the pro-inflammatory cytokine levels positively correlated with HBV viremia [TNF-α (P = 0.004; r = 0.549), IL-1β (P<0.001; r = 0.920), IL-6 (P<0.001; r = 0.777), IFN-γ (P = 0.002; r = 0.579), IL-2 (P = 0.008; r = 0.512) and IL-12 (P<0.001; r = 0.655)]. Also, for women in the Malaria+CHB group, parasitemia was observed to diminish HBV viremia [P = 0.003, r = -0.489]. CONCLUSION: Put together the findings suggests that Malaria+CHB could exacerbate inflammatory cytokine responses and increase susceptibility to liver injury among pregnant women in endemic settings.
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spelling pubmed-64745912019-05-03 Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women Anabire, Nsoh Godwin Aryee, Paul Armah Abdul-Karim, Abass Quaye, Osbourne Awandare, Gordon Akanzuwine Helegbe, Gideon Kofi PLoS One Research Article BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana. METHODS: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). RESULTS: Women with Malaria+CHB maintained appreciably normal hemoglobin levels (mean±SEM = 10.3±0.3 g/dL). That notwithstanding, Liver function test showed significantly elevated levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin [P<0.001 for all comparisons]. Similarly, the Malaria+CHB group had significantly elevated pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 [P<0.05 for all comparisons]. In women with Malaria+CHB, correlation analysis showed significant negative association of the pro-inflammatory cytokines responses with malaria parasitemia [IL-1β (P<0.001; r = -0.645), IL-6 (P = 0.046; r = -0.394) and IL-12 (P = 0.011; r = -0.49)]. On the other hand, the pro-inflammatory cytokine levels positively correlated with HBV viremia [TNF-α (P = 0.004; r = 0.549), IL-1β (P<0.001; r = 0.920), IL-6 (P<0.001; r = 0.777), IFN-γ (P = 0.002; r = 0.579), IL-2 (P = 0.008; r = 0.512) and IL-12 (P<0.001; r = 0.655)]. Also, for women in the Malaria+CHB group, parasitemia was observed to diminish HBV viremia [P = 0.003, r = -0.489]. CONCLUSION: Put together the findings suggests that Malaria+CHB could exacerbate inflammatory cytokine responses and increase susceptibility to liver injury among pregnant women in endemic settings. Public Library of Science 2019-04-19 /pmc/articles/PMC6474591/ /pubmed/31002731 http://dx.doi.org/10.1371/journal.pone.0215550 Text en © 2019 Anabire et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Anabire, Nsoh Godwin
Aryee, Paul Armah
Abdul-Karim, Abass
Quaye, Osbourne
Awandare, Gordon Akanzuwine
Helegbe, Gideon Kofi
Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title_full Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title_fullStr Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title_full_unstemmed Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title_short Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
title_sort impact of malaria and hepatitis b co-infection on clinical and cytokine profiles among pregnant women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474591/
https://www.ncbi.nlm.nih.gov/pubmed/31002731
http://dx.doi.org/10.1371/journal.pone.0215550
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