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Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women
BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474591/ https://www.ncbi.nlm.nih.gov/pubmed/31002731 http://dx.doi.org/10.1371/journal.pone.0215550 |
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author | Anabire, Nsoh Godwin Aryee, Paul Armah Abdul-Karim, Abass Quaye, Osbourne Awandare, Gordon Akanzuwine Helegbe, Gideon Kofi |
author_facet | Anabire, Nsoh Godwin Aryee, Paul Armah Abdul-Karim, Abass Quaye, Osbourne Awandare, Gordon Akanzuwine Helegbe, Gideon Kofi |
author_sort | Anabire, Nsoh Godwin |
collection | PubMed |
description | BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana. METHODS: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). RESULTS: Women with Malaria+CHB maintained appreciably normal hemoglobin levels (mean±SEM = 10.3±0.3 g/dL). That notwithstanding, Liver function test showed significantly elevated levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin [P<0.001 for all comparisons]. Similarly, the Malaria+CHB group had significantly elevated pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 [P<0.05 for all comparisons]. In women with Malaria+CHB, correlation analysis showed significant negative association of the pro-inflammatory cytokines responses with malaria parasitemia [IL-1β (P<0.001; r = -0.645), IL-6 (P = 0.046; r = -0.394) and IL-12 (P = 0.011; r = -0.49)]. On the other hand, the pro-inflammatory cytokine levels positively correlated with HBV viremia [TNF-α (P = 0.004; r = 0.549), IL-1β (P<0.001; r = 0.920), IL-6 (P<0.001; r = 0.777), IFN-γ (P = 0.002; r = 0.579), IL-2 (P = 0.008; r = 0.512) and IL-12 (P<0.001; r = 0.655)]. Also, for women in the Malaria+CHB group, parasitemia was observed to diminish HBV viremia [P = 0.003, r = -0.489]. CONCLUSION: Put together the findings suggests that Malaria+CHB could exacerbate inflammatory cytokine responses and increase susceptibility to liver injury among pregnant women in endemic settings. |
format | Online Article Text |
id | pubmed-6474591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64745912019-05-03 Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women Anabire, Nsoh Godwin Aryee, Paul Armah Abdul-Karim, Abass Quaye, Osbourne Awandare, Gordon Akanzuwine Helegbe, Gideon Kofi PLoS One Research Article BACKGROUND: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana. METHODS: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). RESULTS: Women with Malaria+CHB maintained appreciably normal hemoglobin levels (mean±SEM = 10.3±0.3 g/dL). That notwithstanding, Liver function test showed significantly elevated levels of alanine aminotransferase, aspartate aminotransferase and total bilirubin [P<0.001 for all comparisons]. Similarly, the Malaria+CHB group had significantly elevated pro-inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 [P<0.05 for all comparisons]. In women with Malaria+CHB, correlation analysis showed significant negative association of the pro-inflammatory cytokines responses with malaria parasitemia [IL-1β (P<0.001; r = -0.645), IL-6 (P = 0.046; r = -0.394) and IL-12 (P = 0.011; r = -0.49)]. On the other hand, the pro-inflammatory cytokine levels positively correlated with HBV viremia [TNF-α (P = 0.004; r = 0.549), IL-1β (P<0.001; r = 0.920), IL-6 (P<0.001; r = 0.777), IFN-γ (P = 0.002; r = 0.579), IL-2 (P = 0.008; r = 0.512) and IL-12 (P<0.001; r = 0.655)]. Also, for women in the Malaria+CHB group, parasitemia was observed to diminish HBV viremia [P = 0.003, r = -0.489]. CONCLUSION: Put together the findings suggests that Malaria+CHB could exacerbate inflammatory cytokine responses and increase susceptibility to liver injury among pregnant women in endemic settings. Public Library of Science 2019-04-19 /pmc/articles/PMC6474591/ /pubmed/31002731 http://dx.doi.org/10.1371/journal.pone.0215550 Text en © 2019 Anabire et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Anabire, Nsoh Godwin Aryee, Paul Armah Abdul-Karim, Abass Quaye, Osbourne Awandare, Gordon Akanzuwine Helegbe, Gideon Kofi Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title | Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title_full | Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title_fullStr | Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title_full_unstemmed | Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title_short | Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women |
title_sort | impact of malaria and hepatitis b co-infection on clinical and cytokine profiles among pregnant women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474591/ https://www.ncbi.nlm.nih.gov/pubmed/31002731 http://dx.doi.org/10.1371/journal.pone.0215550 |
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