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Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI

OBJECTIVE: We demonstrate and evaluate the first markerless motion tracker compatible with PET, MRI, and simultaneous PET/MRI systems for motion correction (MC) of brain imaging. METHODS: PET and MRI compatibility is achieved by careful positioning of in-bore vision extenders and by placing all elec...

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Autores principales: Slipsager, Jakob M., Ellegaard, Andreas H., Glimberg, Stefan L., Paulsen, Rasmus R., Tisdall, M. Dylan, Wighton, Paul, van der Kouwe, André, Marner, Lisbeth, Henriksen, Otto M., Law, Ian, Olesen, Oline V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474595/
https://www.ncbi.nlm.nih.gov/pubmed/31002725
http://dx.doi.org/10.1371/journal.pone.0215524
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author Slipsager, Jakob M.
Ellegaard, Andreas H.
Glimberg, Stefan L.
Paulsen, Rasmus R.
Tisdall, M. Dylan
Wighton, Paul
van der Kouwe, André
Marner, Lisbeth
Henriksen, Otto M.
Law, Ian
Olesen, Oline V.
author_facet Slipsager, Jakob M.
Ellegaard, Andreas H.
Glimberg, Stefan L.
Paulsen, Rasmus R.
Tisdall, M. Dylan
Wighton, Paul
van der Kouwe, André
Marner, Lisbeth
Henriksen, Otto M.
Law, Ian
Olesen, Oline V.
author_sort Slipsager, Jakob M.
collection PubMed
description OBJECTIVE: We demonstrate and evaluate the first markerless motion tracker compatible with PET, MRI, and simultaneous PET/MRI systems for motion correction (MC) of brain imaging. METHODS: PET and MRI compatibility is achieved by careful positioning of in-bore vision extenders and by placing all electronic components out-of-bore. The motion tracker is demonstrated in a clinical setup during a pediatric PET/MRI study including 94 pediatric patient scans. PET MC is presented for two of these scans using a customized version of the Multiple Acquisition Frame method. Prospective MC of MRI acquisition of two healthy subjects is demonstrated using a motion-aware MRI sequence. Real-time motion estimates are accompanied with a tracking validity parameter to improve tracking reliability. RESULTS: For both modalities, MC shows that motion induced artifacts are noticeably reduced and that motion estimates are sufficiently accurate to capture motion ranging from small respiratory motion to large intentional motion. In the PET/MRI study, a time-activity curve analysis shows image improvements for a patient performing head movements corresponding to a tumor motion of ±5-10 mm with a 19% maximal difference in standardized uptake value before and after MC. CONCLUSION: The first markerless motion tracker is successfully demonstrated for prospective MC in MRI and MC in PET with good tracking validity. SIGNIFICANCE: As simultaneous PET/MRI systems have become available for clinical use, an increasing demand for accurate motion tracking and MC in PET/MRI scans has emerged. The presented markerless motion tracker facilitate this demand.
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spelling pubmed-64745952019-05-03 Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI Slipsager, Jakob M. Ellegaard, Andreas H. Glimberg, Stefan L. Paulsen, Rasmus R. Tisdall, M. Dylan Wighton, Paul van der Kouwe, André Marner, Lisbeth Henriksen, Otto M. Law, Ian Olesen, Oline V. PLoS One Research Article OBJECTIVE: We demonstrate and evaluate the first markerless motion tracker compatible with PET, MRI, and simultaneous PET/MRI systems for motion correction (MC) of brain imaging. METHODS: PET and MRI compatibility is achieved by careful positioning of in-bore vision extenders and by placing all electronic components out-of-bore. The motion tracker is demonstrated in a clinical setup during a pediatric PET/MRI study including 94 pediatric patient scans. PET MC is presented for two of these scans using a customized version of the Multiple Acquisition Frame method. Prospective MC of MRI acquisition of two healthy subjects is demonstrated using a motion-aware MRI sequence. Real-time motion estimates are accompanied with a tracking validity parameter to improve tracking reliability. RESULTS: For both modalities, MC shows that motion induced artifacts are noticeably reduced and that motion estimates are sufficiently accurate to capture motion ranging from small respiratory motion to large intentional motion. In the PET/MRI study, a time-activity curve analysis shows image improvements for a patient performing head movements corresponding to a tumor motion of ±5-10 mm with a 19% maximal difference in standardized uptake value before and after MC. CONCLUSION: The first markerless motion tracker is successfully demonstrated for prospective MC in MRI and MC in PET with good tracking validity. SIGNIFICANCE: As simultaneous PET/MRI systems have become available for clinical use, an increasing demand for accurate motion tracking and MC in PET/MRI scans has emerged. The presented markerless motion tracker facilitate this demand. Public Library of Science 2019-04-19 /pmc/articles/PMC6474595/ /pubmed/31002725 http://dx.doi.org/10.1371/journal.pone.0215524 Text en © 2019 Slipsager et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Slipsager, Jakob M.
Ellegaard, Andreas H.
Glimberg, Stefan L.
Paulsen, Rasmus R.
Tisdall, M. Dylan
Wighton, Paul
van der Kouwe, André
Marner, Lisbeth
Henriksen, Otto M.
Law, Ian
Olesen, Oline V.
Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title_full Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title_fullStr Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title_full_unstemmed Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title_short Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI
title_sort markerless motion tracking and correction for pet, mri, and simultaneous pet/mri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474595/
https://www.ncbi.nlm.nih.gov/pubmed/31002725
http://dx.doi.org/10.1371/journal.pone.0215524
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