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High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias

BACKGROUND/AIMS: It is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. Hyperglycemia is an important cause of gastric slow wave dysrhythmia, however, the spatiotemporal patterns of dysrhythmias in this context have not been investigated. This stu...

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Autores principales: Du, Peng, O’Grady, Gregory, Paskaranandavadivel, Niranchan, Tang, Shou-jiang, Abell, Thomas, Cheng, Leo K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Neurogastroenterology and Motility 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474709/
https://www.ncbi.nlm.nih.gov/pubmed/30870879
http://dx.doi.org/10.5056/jnm18192
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author Du, Peng
O’Grady, Gregory
Paskaranandavadivel, Niranchan
Tang, Shou-jiang
Abell, Thomas
Cheng, Leo K
author_facet Du, Peng
O’Grady, Gregory
Paskaranandavadivel, Niranchan
Tang, Shou-jiang
Abell, Thomas
Cheng, Leo K
author_sort Du, Peng
collection PubMed
description BACKGROUND/AIMS: It is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. Hyperglycemia is an important cause of gastric slow wave dysrhythmia, however, the spatiotemporal patterns of dysrhythmias in this context have not been investigated. This study aims to investigate the relationship between hyperglycemia and the patterns of dysrhythmias by employing high-resolution (multi-electrode) mapping simultaneously at the anterior and posterior gastric serosa. METHODS: High-resolution mapping (8 × 16 electrodes per serosal) was performed in 4 anesthetized hounds. Baseline recordings (21 ± 8 minutes) were followed by intravenous injection of glucagon (0.5 mg per dose) and further recordings (59 ± 15 minutes). Blood glucose levels were monitored manually using a glucose sensing kit at regular 5-minute intervals. Slow wave activation maps, amplitudes, velocity, anisotropic ratio, and frequency were calculated. Differences were compared between baseline and post glucagon injection. RESULTS: Baseline slow waves propagated symmetrically and antegrade. The blood glucose levels were increased by an average of 112% compared to the baseline by the end of the recordings. All subjects demonstrated elevated incidence of slow wave dysrhythmias following injection compared to the baseline (48 ± 23% vs 6 ± 4%, P < 0.05). Dysrhythmias arose simultaneously or independently on anterior and posterior serosa. Spatial dysrhythmias occurred before and persisted after the onset and disappearance of temporal dysrhythmias. CONCLUSIONS: Infusion of glucagon induced gastric slow wave dysrhythmias, which occurred across a heterogeneous range of patterns and frequencies. The spatial dysrhythmias of gastric slow waves were shown to be more prevalent and persisted over a longer period of time compared to the temporal dysrhythmias.
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spelling pubmed-64747092019-04-26 High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias Du, Peng O’Grady, Gregory Paskaranandavadivel, Niranchan Tang, Shou-jiang Abell, Thomas Cheng, Leo K J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: It is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. Hyperglycemia is an important cause of gastric slow wave dysrhythmia, however, the spatiotemporal patterns of dysrhythmias in this context have not been investigated. This study aims to investigate the relationship between hyperglycemia and the patterns of dysrhythmias by employing high-resolution (multi-electrode) mapping simultaneously at the anterior and posterior gastric serosa. METHODS: High-resolution mapping (8 × 16 electrodes per serosal) was performed in 4 anesthetized hounds. Baseline recordings (21 ± 8 minutes) were followed by intravenous injection of glucagon (0.5 mg per dose) and further recordings (59 ± 15 minutes). Blood glucose levels were monitored manually using a glucose sensing kit at regular 5-minute intervals. Slow wave activation maps, amplitudes, velocity, anisotropic ratio, and frequency were calculated. Differences were compared between baseline and post glucagon injection. RESULTS: Baseline slow waves propagated symmetrically and antegrade. The blood glucose levels were increased by an average of 112% compared to the baseline by the end of the recordings. All subjects demonstrated elevated incidence of slow wave dysrhythmias following injection compared to the baseline (48 ± 23% vs 6 ± 4%, P < 0.05). Dysrhythmias arose simultaneously or independently on anterior and posterior serosa. Spatial dysrhythmias occurred before and persisted after the onset and disappearance of temporal dysrhythmias. CONCLUSIONS: Infusion of glucagon induced gastric slow wave dysrhythmias, which occurred across a heterogeneous range of patterns and frequencies. The spatial dysrhythmias of gastric slow waves were shown to be more prevalent and persisted over a longer period of time compared to the temporal dysrhythmias. Korean Society of Neurogastroenterology and Motility 2019-04 2019-04-30 /pmc/articles/PMC6474709/ /pubmed/30870879 http://dx.doi.org/10.5056/jnm18192 Text en © 2019 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Du, Peng
O’Grady, Gregory
Paskaranandavadivel, Niranchan
Tang, Shou-jiang
Abell, Thomas
Cheng, Leo K
High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title_full High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title_fullStr High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title_full_unstemmed High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title_short High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
title_sort high-resolution mapping of hyperglycemia-induced gastric slow wave dysrhythmias
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474709/
https://www.ncbi.nlm.nih.gov/pubmed/30870879
http://dx.doi.org/10.5056/jnm18192
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