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Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

RAS genes are the most commonly mutated oncogenes in human cancers. Despite tremendous efforts over the past several decades, however, RAS-specific inhibitors remain elusive. Thus, targeting RAS remains a highly sought after goal of cancer research. Previously, we reported a new approach to inhibit...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Khan, Imran, Spencer-Smith, Russell, O’Bryan, John P.
التنسيق: Online مقال نص
اللغة:English
منشور في: 2018
الموضوعات:
الوصول للمادة أونلاين:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474814/
https://www.ncbi.nlm.nih.gov/pubmed/30573767
http://dx.doi.org/10.1038/s41388-018-0636-y