A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration

Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2 in DA neurons. Transgenic knockdown of Furin1 or its substrate the bone morphogenic protein...

Descripción completa

Detalles Bibliográficos
Autores principales: Maksoud, Elie, Liao, Edward H., Haghighi, A. Pejmun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474846/
https://www.ncbi.nlm.nih.gov/pubmed/30759389
http://dx.doi.org/10.1016/j.celrep.2019.01.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474846/
https://www.ncbi.nlm.nih.gov/pubmed/30759389
http://dx.doi.org/10.1016/j.celrep.2019.01.077

Ejemplares similares