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A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration
Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) induce an age-dependent loss of dopaminergic (DA) neurons. We have identified Furin 1, a pro-protein convertase, as a translational target of LRRK2 in DA neurons. Transgenic knockdown of Furin1 or its substrate the bone morphogenic protein...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474846/ https://www.ncbi.nlm.nih.gov/pubmed/30759389 http://dx.doi.org/10.1016/j.celrep.2019.01.077 |