Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts

As patient derived xenograft (PDX) models are increasingly used for preclinical drug development, strategies to account for the nonhuman component of PDX RNA expression data are critical to its interpretation. A bioinformatics pipeline to separate donor tumor and mouse stroma transcriptome profiles...

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Detalles Bibliográficos
Autores principales: Liu, Yuanhang, Chanana, Pritha, Davila, Jaime I., Hou, Xiaonan, Zanfagnin, Valentina, McGehee, Cordelia D., Goode, Ellen L., Polley, Eric C., Haluska, Paul, Weroha, S. John, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474864/
https://www.ncbi.nlm.nih.gov/pubmed/31004097
http://dx.doi.org/10.1038/s41598-019-42680-2

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