Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro

Angiosarcomas are highly aggressive tumors of endothelial origin, which carry a poor prognosis. Fenofibrate is a hypolipidemic drug, which acts by activating the transcription factor PPARα. It has also been widely reported to have ‘anti-cancer’ activity. The current study investigated its effect in...

Descripción completa

Detalles Bibliográficos
Autores principales: Majeed, Yasser, Upadhyay, Rohit, Alhousseiny, Sara, Taha, Tarek, Musthak, Adham, Shaheen, Yanal, Jameel, Mohtashim, Triggle, Chris R., Ding, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474884/
https://www.ncbi.nlm.nih.gov/pubmed/31004117
http://dx.doi.org/10.1038/s41598-019-42838-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474884/
https://www.ncbi.nlm.nih.gov/pubmed/31004117
http://dx.doi.org/10.1038/s41598-019-42838-y

Ejemplares similares