Studying the rigidity of red blood cells induced by Plasmodium falciparum infection

We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs i...

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Autores principales: Paul, Apurba, Ramdani, Ghania, Tatu, Utpal, Langsley, Gordon, Natarajan, Vasant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474899/
https://www.ncbi.nlm.nih.gov/pubmed/31004094
http://dx.doi.org/10.1038/s41598-019-42721-w
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author Paul, Apurba
Ramdani, Ghania
Tatu, Utpal
Langsley, Gordon
Natarajan, Vasant
author_facet Paul, Apurba
Ramdani, Ghania
Tatu, Utpal
Langsley, Gordon
Natarajan, Vasant
author_sort Paul, Apurba
collection PubMed
description We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.
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spelling pubmed-64748992019-04-26 Studying the rigidity of red blood cells induced by Plasmodium falciparum infection Paul, Apurba Ramdani, Ghania Tatu, Utpal Langsley, Gordon Natarajan, Vasant Sci Rep Article We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity. Nature Publishing Group UK 2019-04-19 /pmc/articles/PMC6474899/ /pubmed/31004094 http://dx.doi.org/10.1038/s41598-019-42721-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Paul, Apurba
Ramdani, Ghania
Tatu, Utpal
Langsley, Gordon
Natarajan, Vasant
Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title_full Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title_fullStr Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title_full_unstemmed Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title_short Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
title_sort studying the rigidity of red blood cells induced by plasmodium falciparum infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474899/
https://www.ncbi.nlm.nih.gov/pubmed/31004094
http://dx.doi.org/10.1038/s41598-019-42721-w
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