Cargando…

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP(5+) Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

BACKGROUND: Aortic valve sclerosis (AVSc), the early asymptomatic presentation of calcific aortic valve (AV) disease, affects 25% to 30% of patients aged >65 years. In vitro and ex vivo experiments with antioxidant strategies and antagonists of osteogenic differentiation revealed that AVSc is rev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anselmo, Wanda, Branchetti, Emanuela, Grau, Juan B., Li, Gen, Ayoub, Salma, Lai, Eric K., Rioux, Nancy, Tovmasyan, Artak, Fortier, Jacqueline H., Sacks, Michael S., Batinic‐Haberle, Ines, Hazen, Stanley L., Levy, Robert J., Ferrari, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474974/ https://www.ncbi.nlm.nih.gov/pubmed/30371255 http://dx.doi.org/10.1161/JAHA.117.007861

Ejemplares similares

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP(5+), Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line
por: Chaiswing, Luksana, et al.
Publicado: (2022)

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP(5+)
por: Leu, David, et al.
Publicado: (2017)

A novel redox regulator, MnTnBuOE-2-PyP(5+), enhances normal hematopoietic stem/progenitor cell function
por: Zhao, Y., et al.
Publicado: (2017)

Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP(5+), prevents its acute hypotensive response
por: Schlichte, Sarah L., et al.
Publicado: (2020)

Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP(5+), following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats
por: Li, Xuan, et al.
Publicado: (2023)

MnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer
por: Patel, Anery, et al.
Publicado: (2019)

Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment
por: McElroy, Taylor, et al.
Publicado: (2020)

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP(5+), Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin
por: Soares, Rita B., et al.
Publicado: (2023)

Mn(III) Porphyrin, MnTnBuOE-2-PyP(5+), Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress
por: Sharma, Sudha, et al.
Publicado: (2023)

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells
por: Kosmacek, Elizabeth A., et al.
Publicado: (2016)

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+)()
por: Gauter-Fleckenstein, Benjamin, et al.
Publicado: (2014)

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP(4+), in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H(2)O)MnTnHex-2-PyP(5+)
por: Li, Litao, et al.
Publicado: (2020)

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum()
por: Archambeau, John O., et al.
Publicado: (2013)

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP(5+), Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation
por: Cline, John Mark, et al.
Publicado: (2018)

The SOD Mimic MnTnHex-2-PyP(5+) Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
por: Costa, João G., et al.
Publicado: (2019)

MnTnHex-2-PyP(5+), Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways
por: Shin, Sung-Won, et al.
Publicado: (2021)

The manganese(III) porphyrin MnTnHex-2-PyP(5+) modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
por: Flórido, Ana, et al.
Publicado: (2018)

MnTnHex-2-PyP(5+) Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
por: Soares, Rita B., et al.
Publicado: (2022)

Photoinactivation of Yeast and Biofilm Communities of Candida albicans Mediated by ZnTnHex-2-PyP(4+) Porphyrin
por: Souza, Sueden O., et al.
Publicado: (2022)

Corrigendum to ‘An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways’ [Redox Biology 5C (2015) 43–65]
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

Antibacterial Activity of Synthetic Cationic Iron Porphyrins
por: Tovmasyan, Artak, et al.
Publicado: (2020)

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes
por: Hasan, Bader, et al.
Publicado: (2021)

Predictors of Mortality Following Aortic Valve Replacement in Aortic Stenosis Patients
por: Shvartz, Vladimir, et al.
Publicado: (2022)

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance
por: Al-Mutairi, Rawan, et al.
Publicado: (2018)

Transcatheter Aortic Valve Implantation for Bioprosthetic Valve Failure: Placement of Aortic Transcatheter Valves 3 Aortic Valve-in-Valve Study
por: Malaisrie, S. Chris, et al.
Publicado: (2022)

Bioprosthetic Aortic Valve Fracture During Valve-in-valve Transcatheter Aortic Valve Implantation
por: O’Donnell, John Phineas, et al.
Publicado: (2019)

Aortic valve anatomy and outcomes after transcatheter aortic valve implantation in bicuspid aortic valves
por: De Biase, Chiara, et al.
Publicado: (2018)

Post-illumination cellular effects of photodynamic treatment
por: Charara, Malak, et al.
Publicado: (2017)

Functional differences in human aortic valve interstitial cells from patients with varying calcific aortic valve disease
por: Tuscher, Robin, et al.
Publicado: (2023)

Aortic valve endocarditis in patients with bicuspid and tricuspid aortic valves
por: Le, Tan, et al.
Publicado: (2021)

Transcatheter Aortic Valve Therapy for Bicuspid Aortic Valve Stenosis
por: Dayawansa, Nalin H., et al.
Publicado: (2023)

Redox-Active Drug, MnTE-2-PyP(5+), Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function
por: Barbosa, Andrezza M., et al.
Publicado: (2020)

Functional and pathomorphological anatomy of the aortic valve and root for aortic valve sparing surgery in tricuspid and bicuspid aortic valves
por: Jahanyar, Jama, et al.
Publicado: (2023)

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications()
por: Ali, Dana K., et al.
Publicado: (2013)

Transcatheter Aortic Valve Replacement Valve in Transcatheter Aortic Valve Replacement Valve for Severe Periprosthetic Regurgitation
por: Nandy, Sneha, et al.
Publicado: (2020)

Surgical Aortic Valve Replacement to Treat Prosthetic Valve Endocarditis After Valve-in-Valve Transcatheter Aortic Valve Replacement
por: Jena, Nihar, et al.
Publicado: (2023)

Bicuspid Aortic Valve in Pregnancy Complicated by Aortic Valve Vegetation, Aortic Root Abscess, and Aortic Insufficiency
por: He, Shan, et al.
Publicado: (2021)

Valve selection in aortic valve endocarditis
por: Perrotta, Sossio, et al.
Publicado: (2016)

Transcatheter CoreValve valve-in-valve implantation in a stentless porcine aortic valve for severe aortic regurgitation
por: Yong, Celina M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pesp4bhlseaa2celc2bl1t1joe