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Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease
BACKGROUND: Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure (SBP) and cardiovascular e...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475052/ https://www.ncbi.nlm.nih.gov/pubmed/30845872 http://dx.doi.org/10.1161/JAHA.118.010748 |
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author | Thomas Manapurathe, Diana Moxon, Joseph Vaughan Krishna, Smriti Murali Rowbotham, Sophie Quigley, Frank Jenkins, Jason Bourke, Michael Bourke, Bernard Jones, Rhondda E. Golledge, Jonathan |
author_facet | Thomas Manapurathe, Diana Moxon, Joseph Vaughan Krishna, Smriti Murali Rowbotham, Sophie Quigley, Frank Jenkins, Jason Bourke, Michael Bourke, Bernard Jones, Rhondda E. Golledge, Jonathan |
author_sort | Thomas Manapurathe, Diana |
collection | PubMed |
description | BACKGROUND: Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure (SBP) and cardiovascular events in a prospectively recruited patient cohort with peripheral artery disease. METHODS AND RESULTS: A total of 2773 patients were included and were grouped according to SBP at recruitment (≤120 mm Hg, n=604; 121–140 mm Hg, n=1065; and >140 mm Hg, n=1104). Adjusted Cox proportional hazards analyses suggested that patients with SBP ≤120 mm Hg were at greater risk of having a major cardiovascular event (myocardial infarction, stroke, or cardiovascular death) than patients with SBP of 121–140 mm Hg (adjusted hazard ratio, 1.36; 95% CI, 1.08–1.72; P=0.009). Patients with SBP >140 mm Hg had an adjusted hazard ratio of 1.23 (95% CI, 1.00–1.51; P=0.051) of major cardiovascular events compared with patients with SBP of 121–140 mm Hg. These findings were similar in sensitivity analyses only including patients receiving antihypertensive medications or focused on patients with a minimum of 3 months of follow‐up. CONCLUSIONS: This cohort study suggests that patients with peripheral artery disease and SBP ≤120 mm Hg are at increased risk of major cardiovascular events. The findings suggest caution in intensive SBP lowering in this patient group. |
format | Online Article Text |
id | pubmed-6475052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64750522019-04-24 Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease Thomas Manapurathe, Diana Moxon, Joseph Vaughan Krishna, Smriti Murali Rowbotham, Sophie Quigley, Frank Jenkins, Jason Bourke, Michael Bourke, Bernard Jones, Rhondda E. Golledge, Jonathan J Am Heart Assoc Original Research BACKGROUND: Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure (SBP) and cardiovascular events in a prospectively recruited patient cohort with peripheral artery disease. METHODS AND RESULTS: A total of 2773 patients were included and were grouped according to SBP at recruitment (≤120 mm Hg, n=604; 121–140 mm Hg, n=1065; and >140 mm Hg, n=1104). Adjusted Cox proportional hazards analyses suggested that patients with SBP ≤120 mm Hg were at greater risk of having a major cardiovascular event (myocardial infarction, stroke, or cardiovascular death) than patients with SBP of 121–140 mm Hg (adjusted hazard ratio, 1.36; 95% CI, 1.08–1.72; P=0.009). Patients with SBP >140 mm Hg had an adjusted hazard ratio of 1.23 (95% CI, 1.00–1.51; P=0.051) of major cardiovascular events compared with patients with SBP of 121–140 mm Hg. These findings were similar in sensitivity analyses only including patients receiving antihypertensive medications or focused on patients with a minimum of 3 months of follow‐up. CONCLUSIONS: This cohort study suggests that patients with peripheral artery disease and SBP ≤120 mm Hg are at increased risk of major cardiovascular events. The findings suggest caution in intensive SBP lowering in this patient group. John Wiley and Sons Inc. 2019-03-08 /pmc/articles/PMC6475052/ /pubmed/30845872 http://dx.doi.org/10.1161/JAHA.118.010748 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Thomas Manapurathe, Diana Moxon, Joseph Vaughan Krishna, Smriti Murali Rowbotham, Sophie Quigley, Frank Jenkins, Jason Bourke, Michael Bourke, Bernard Jones, Rhondda E. Golledge, Jonathan Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title | Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title_full | Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title_fullStr | Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title_full_unstemmed | Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title_short | Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease |
title_sort | cohort study examining the association between blood pressure and cardiovascular events in patients with peripheral artery disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475052/ https://www.ncbi.nlm.nih.gov/pubmed/30845872 http://dx.doi.org/10.1161/JAHA.118.010748 |
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