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Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates

BACKGROUND: Omaveloxolone is a synthetic oleanane triterpenoid that pharmacologically activates Nrf2, a master transcription factor that regulates genes with antioxidative, anti-inflammatory, and mitochondrial bioenergetic properties, and is being evaluated in patients with Friedreich’s ataxia. METH...

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Detalles Bibliográficos
Autores principales:	Reisman, Scott A, Gahir, Sarabjit S, Lee, Chun-Yue I, Proksch, Joel W, Sakamoto, Mitsumasa, Ward, Keith W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475100/ https://www.ncbi.nlm.nih.gov/pubmed/31118567 http://dx.doi.org/10.2147/DDDT.S193889

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