Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF

Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we f...

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Autores principales: Weatherley, Nicholas D, Stewart, Neil J, Chan, Ho-Fung, Austin, Matthew, Smith, Laurie J, Collier, Guilhem, Rao, Madhwesha, Marshall, Helen, Norquay, Graham, Renshaw, Stephen A, Bianchi, Stephen Mark, Wild, Jim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475110/
https://www.ncbi.nlm.nih.gov/pubmed/30389827
http://dx.doi.org/10.1136/thoraxjnl-2018-211851
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author Weatherley, Nicholas D
Stewart, Neil J
Chan, Ho-Fung
Austin, Matthew
Smith, Laurie J
Collier, Guilhem
Rao, Madhwesha
Marshall, Helen
Norquay, Graham
Renshaw, Stephen A
Bianchi, Stephen Mark
Wild, Jim M
author_facet Weatherley, Nicholas D
Stewart, Neil J
Chan, Ho-Fung
Austin, Matthew
Smith, Laurie J
Collier, Guilhem
Rao, Madhwesha
Marshall, Helen
Norquay, Graham
Renshaw, Stephen A
Bianchi, Stephen Mark
Wild, Jim M
author_sort Weatherley, Nicholas D
collection PubMed
description Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised (129)Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF.
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spelling pubmed-64751102019-05-07 Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF Weatherley, Nicholas D Stewart, Neil J Chan, Ho-Fung Austin, Matthew Smith, Laurie J Collier, Guilhem Rao, Madhwesha Marshall, Helen Norquay, Graham Renshaw, Stephen A Bianchi, Stephen Mark Wild, Jim M Thorax Brief Communication Prognosticating idiopathic pulmonary fibrosis (IPF) is challenging, in part due to a lack of sensitive biomarkers. A recent article in Thorax described how hyperpolarised xenon magnetic resonance spectroscopy may quantify regional gas exchange in IPF lungs. In a population of patients with IPF, we find that the xenon signal from red blood cells diminishes relative to the tissue/plasma signal over a 12-month time period, even when the diffusion factor for carbon monoxide is static over the same time period. We conclude that hyperpolarised (129)Xe MR spectroscopy may be sensitive to short-term changes in interstitial gas diffusion in IPF. BMJ Publishing Group 2019-05 2018-11-02 /pmc/articles/PMC6475110/ /pubmed/30389827 http://dx.doi.org/10.1136/thoraxjnl-2018-211851 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Weatherley, Nicholas D
Stewart, Neil J
Chan, Ho-Fung
Austin, Matthew
Smith, Laurie J
Collier, Guilhem
Rao, Madhwesha
Marshall, Helen
Norquay, Graham
Renshaw, Stephen A
Bianchi, Stephen Mark
Wild, Jim M
Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title_full Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title_fullStr Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title_full_unstemmed Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title_short Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF
title_sort hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in ipf
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475110/
https://www.ncbi.nlm.nih.gov/pubmed/30389827
http://dx.doi.org/10.1136/thoraxjnl-2018-211851
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