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Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population

AIM: Physical activity plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). However, the optimal intensity and dose of physical activity for the treatment of NAFLD have yet to be found. In the present study, we aimed to provide a dose–response association between...

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Autores principales: Li, YangFan, He, Fei, He, Yun, Pan, XinTing, Wu, YunLi, Hu, ZhiJian, Lin, Xu, Peng, Xian-E, Xu, ShangHua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475196/
https://www.ncbi.nlm.nih.gov/pubmed/30928957
http://dx.doi.org/10.1136/bmjopen-2018-026854
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author Li, YangFan
He, Fei
He, Yun
Pan, XinTing
Wu, YunLi
Hu, ZhiJian
Lin, Xu
Peng, Xian-E
Xu, ShangHua
author_facet Li, YangFan
He, Fei
He, Yun
Pan, XinTing
Wu, YunLi
Hu, ZhiJian
Lin, Xu
Peng, Xian-E
Xu, ShangHua
author_sort Li, YangFan
collection PubMed
description AIM: Physical activity plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). However, the optimal intensity and dose of physical activity for the treatment of NAFLD have yet to be found. In the present study, we aimed to provide a dose–response association between physical activity and NAFLD in a Chinese population. METHODS: We recruited 543 patients with NAFLD diagnosed by abdominal ultrasonography, and 543 age-matched and sex-matched controls. The amount of physical activity, sedentary time and energy intake was collected through a structured questionnaire. Logistic regression analyses were performed to investigate the association between physical activity and NAFLD. RESULTS: After adjusting for hypertension, diabetes, body mass index, fasting blood glucose, energy intake and sedentary time, the total amount of physical activity was found to be inversely associated with NAFLD in a dose-dependent manner in men (>3180 metabolic equivalent of energy [MET]-min/week vs ≤1440 MET-min/week: OR 0.60, 95% CI 0.40 to 0.91, p for trend=0.01). In addition, both moderate-intensity and vigorous-intensity physical activity were effective in reducing the risk of NAFLD, independent of confounding variables in men (moderate-intensity physical activity: >684 MET-min/week vs none: OR 0.58, 95% CI 0.40 to 0.86, p for trend=0.01; vigorous-intensity physical activity: >960 MET-min/week vs none: OR 0.63, 95% CI 0.41 to 0.95, p for trend=0.02). CONCLUSIONS: Physical activity was inversely associated with risk of NAFLD in a dose-dependent manner in men. Vigorous-intensity and moderate-intensity physical activity were both beneficial to NAFLD, independent of sedentary time and energy intake.
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spelling pubmed-64751962019-05-07 Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population Li, YangFan He, Fei He, Yun Pan, XinTing Wu, YunLi Hu, ZhiJian Lin, Xu Peng, Xian-E Xu, ShangHua BMJ Open Gastroenterology and Hepatology AIM: Physical activity plays an important role in the development of non-alcoholic fatty liver disease (NAFLD). However, the optimal intensity and dose of physical activity for the treatment of NAFLD have yet to be found. In the present study, we aimed to provide a dose–response association between physical activity and NAFLD in a Chinese population. METHODS: We recruited 543 patients with NAFLD diagnosed by abdominal ultrasonography, and 543 age-matched and sex-matched controls. The amount of physical activity, sedentary time and energy intake was collected through a structured questionnaire. Logistic regression analyses were performed to investigate the association between physical activity and NAFLD. RESULTS: After adjusting for hypertension, diabetes, body mass index, fasting blood glucose, energy intake and sedentary time, the total amount of physical activity was found to be inversely associated with NAFLD in a dose-dependent manner in men (>3180 metabolic equivalent of energy [MET]-min/week vs ≤1440 MET-min/week: OR 0.60, 95% CI 0.40 to 0.91, p for trend=0.01). In addition, both moderate-intensity and vigorous-intensity physical activity were effective in reducing the risk of NAFLD, independent of confounding variables in men (moderate-intensity physical activity: >684 MET-min/week vs none: OR 0.58, 95% CI 0.40 to 0.86, p for trend=0.01; vigorous-intensity physical activity: >960 MET-min/week vs none: OR 0.63, 95% CI 0.41 to 0.95, p for trend=0.02). CONCLUSIONS: Physical activity was inversely associated with risk of NAFLD in a dose-dependent manner in men. Vigorous-intensity and moderate-intensity physical activity were both beneficial to NAFLD, independent of sedentary time and energy intake. BMJ Publishing Group 2019-03-30 /pmc/articles/PMC6475196/ /pubmed/30928957 http://dx.doi.org/10.1136/bmjopen-2018-026854 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Gastroenterology and Hepatology
Li, YangFan
He, Fei
He, Yun
Pan, XinTing
Wu, YunLi
Hu, ZhiJian
Lin, Xu
Peng, Xian-E
Xu, ShangHua
Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title_full Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title_fullStr Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title_full_unstemmed Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title_short Dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a Chinese population
title_sort dose–response association between physical activity and non-alcoholic fatty liver disease: a case–control study in a chinese population
topic Gastroenterology and Hepatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475196/
https://www.ncbi.nlm.nih.gov/pubmed/30928957
http://dx.doi.org/10.1136/bmjopen-2018-026854
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