Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and C3 glomerulopathy. Moreover, glomerular Ig deposits can lead to complement-driven nephropathies. Here we des...

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Detalles Bibliográficos
Autores principales: Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Mac Sweeney, Aengus, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475383/
https://www.ncbi.nlm.nih.gov/pubmed/30926668
http://dx.doi.org/10.1073/pnas.1820892116

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